LEF1

GENE INFORMATION

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Gene name

LEF1 (HGNC Symbol)

Synonyms

TCF10, TCF1ALPHA, TCF7L3

Description

Lymphoid enhancer-binding factor 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Chromosome

4

Cytoband

q25

Chromosome location (bp)

108047545 - 108168956

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000138795 (version 78.38)

Entrez gene

51176

UniProt

Q9UJU2 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UJU2

Antibodypedia

LEF1 antibodies
 

PROTEIN VIEW

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LEF1-001
 
LEF1-003
 
LEF1-006
 
LEF1-018
 
LEF1-020
 
LEF1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LEF1-001 ENSP00000265165
ENST00000265165
Q9UJU2
Show all »
Show » Show » 399 44.2 No 0
LEF1-003 ENSP00000422801
ENST00000515500
D6RAB1
Show all »
Show » Show » 173 18.8 No 0
LEF1-006 ENSP00000427365
ENST00000512172
D6RIV1
Show all »
Show » Show » 145 15.8 No 0
LEF1-018 ENSP00000422840
ENST00000510624
Q9UJU2
Show all »
Show » Show » 303 34.1 No 0
LEF1-020 ENSP00000406176
ENST00000438313
Q9UJU2
Show all »
Show » Show » 371 41.2 No 0
LEF1-201 ENSP00000369284
ENST00000379951
Q9UJU2
Show all »
Show » Show » 386 42.7 No 0