ITGB7

GENE INFORMATION

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Gene name

ITGB7

Synonyms

Description

Integrin, beta 7 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that is a member of the integrin superfamily. Members of this family are adhesion receptors that function in signaling from the extracellular matrix to the cell. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The encoded protein forms dimers with an alpha4 chain or an alphaE chain and plays a role in leukocyte adhesion. Dimerization with alpha4 forms a homing receptor for migration of lymphocytes to the intestinal mucosa and Peyer's patches. Dimerization with alphaE permits binding to the ligand epithelial cadherin, a calcium-dependent adhesion molecule. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]

Chromosome

12

Cytoband

q13.13

Chromosome location (bp)

53191318 - 53207307

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000139626 (version 78.38)

Entrez gene

3695

UniProt

P26010 (UniProt - Evidence at protein level)

neXtProt

NX_P26010

Antibodypedia

ITGB7 antibodies
 

PROTEIN VIEW

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ITGB7-004
 
ITGB7-005
 
ITGB7-006
 
ITGB7-007
 
ITGB7-011
 
ITGB7-013
 
ITGB7-014
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ITGB7-004 ENSP00000267082
ENST00000267082
P26010
Show all »
Show » Show » 798 86.9 Yes 1
ITGB7-005 ENSP00000408741
ENST00000422257
P26010
Show all »
Show » Show » 798 86.9 Yes 1
ITGB7-006 ENSP00000456305
ENST00000552935
H3BRM2
Show all »
Show » Show » 93 10.1 Yes 0
ITGB7-007 ENSP00000446703
ENST00000549086
F8W186
Show all »
Show » Show » 89 9.8 Yes 0
ITGB7-011 ENSP00000450366
ENST00000552972
F8VNX4
Show all »
Show » Show » 158 17.5 Yes 0
ITGB7-013 ENSP00000455374
ENST00000550743
P26010
Show all »
Show » Show » 650 71.6 Yes 1
ITGB7-014 ENSP00000456446
ENST00000551319
Show » 117 12.9 No 1