SORD

GENE INFORMATION

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Gene name

SORD

Synonyms

Description

Sorbitol dehydrogenase (HGNC Symbol)

Entrez gene summary

Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.[supplied by OMIM, Jul 2010]

Chromosome

15

Cytoband

q21.1

Chromosome location (bp)

45023104 - 45077185

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000140263 (version 78.38)

Entrez gene

6652

UniProt

Q00796 (UniProt - Evidence at protein level)

neXtProt

NX_Q00796

Antibodypedia

SORD antibodies
 

PROTEIN VIEW

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SORD-001
 
SORD-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SORD-001 ENSP00000267814
ENST00000267814
Q00796
Show all »
Show » Show » 357 38.3 No 0
SORD-004 ENSP00000453122
ENST00000558580
H0YLA4
Show all »
Show » Show » 336 36.2 No 0