SLC27A2

GENE INFORMATION

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Gene name

SLC27A2 (HGNC Symbol)

Synonyms

ACSVL1, FACVL1, FATP2, hFACVL1, HsT17226, VLACS, VLCS

Description

Solute carrier family 27 (fatty acid transporter), member 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

Chromosome

15

Cytoband

q21.2

Chromosome location (bp)

50182196 - 50236395

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000140284 (version 78.38)

Entrez gene

11001

UniProt

O14975 (UniProt - Evidence at protein level)

neXtProt

NX_O14975

Antibodypedia

SLC27A2 antibodies
 

PROTEIN VIEW

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SLC27A2-001
 
SLC27A2-002
 
SLC27A2-003
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC27A2-001 ENSP00000267842
ENST00000267842
O14975
Show all »
Show » Show » 620 70.3 Yes 2
SLC27A2-002 ENSP00000370289
ENST00000380902
O14975
Show all »
Show » Show » 567 64.6 Yes 1
SLC27A2-003 ENSP00000444549
ENST00000544960
G3V1R7
Show all »
Show » Show » 385 44 No 1