PCSK6

GENE INFORMATION

? »

Gene name

PCSK6 (HGNC Symbol)

Synonyms

PACE4, SPC4

Description

Proprotein convertase subtilisin/kexin type 6 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. The encoded protease is constitutively secreted into the extracellular matrix and expressed in many tissues, including neuroendocrine, liver, gut, and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include transforming growth factor beta related proteins, proalbumin, and von Willebrand factor. This gene is thought to play a role in tumor progression and left-right patterning. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2014]

Chromosome

15

Cytoband

q26.3

Chromosome location (bp)

101297142 - 101525202

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000140479 (version 78.38)

Entrez gene

5046

UniProt

P29122 (UniProt - Evidence at protein level)

neXtProt

NX_P29122

Antibodypedia

PCSK6 antibodies
 

PROTEIN VIEW

? »
 
 
 « 
 
PCSK6-001
 
PCSK6-002
 
PCSK6-003
 
PCSK6-004
 
PCSK6-005
 
PCSK6-008
 
PCSK6-010
 
PCSK6-011
 
PCSK6-012
 
PCSK6-016
 
PCSK6-017
 
PCSK6-019
 
PCSK6-201
 
 » 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PCSK6-001 ENSP00000482760
ENST00000611716
P29122
Show all »
Show » Show » 969 106.4 No 0
PCSK6-002 ENSP00000477768
ENST00000611967
P29122
Show all »
Show » Show » 652 71.8 No 0
PCSK6-003 ENSP00000481556
ENST00000622483
A2RQD9
Show all »
Show » Show » 975 106.6 No 0
PCSK6-004 ENSP00000482831
ENST00000619160
A2RQD9
Show all »
Show » Show » 962 105.3 No 0
PCSK6-005 ENSP00000479496
ENST00000618548
P29122
Show all »
Show » Show » 956 105.1 No 0
PCSK6-008 ENSP00000381246
ENST00000398185
H0Y3Q0
Show all »
Show » Show » 797 88.6 No 0
PCSK6-010 ENSP00000452997
ENST00000559417
Show » Show » 345 38 No 0
PCSK6-011 ENSP00000452839
ENST00000558864
Show » 77 8.3 No 0
PCSK6-012 ENSP00000453771
ENST00000558951
H0YMW5
Show all »
Show » Show » 125 14.1 No 0
PCSK6-016 ENSP00000483048
ENST00000621185
Show » Show » 142 16.2 No 0
PCSK6-017 ENSP00000453155
ENST00000559605
Show » 126 13.1 No 0
PCSK6-019 ENSP00000478081
ENST00000615296
P29122
Show all »
Show » Show » 623 68.2 No 0
PCSK6-201 ENSP00000332052
ENST00000331826
A2RQD9
Show all »
Show » Show » 664 73 No 0