ITGAX

GENE INFORMATION

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Gene name

ITGAX (HGNC Symbol)

Synonyms

CD11C

Description

Integrin, alpha X (complement component 3 receptor 4 subunit) (HGNC Symbol)

Entrez gene summary

This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Chromosome

16

Cytoband

p11.2

Chromosome location (bp)

31355134 - 31382997

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000140678 (version 78.38)

Entrez gene

3687

UniProt

P20702 (UniProt - Evidence at protein level)

neXtProt

NX_P20702

Antibodypedia

ITGAX antibodies
 

PROTEIN VIEW

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ITGAX-001
 
ITGAX-003
 
ITGAX-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ITGAX-001 ENSP00000268296
ENST00000268296
P20702
Show all »
Show » Show » 1163 127.8 Yes 1
ITGAX-003 ENSP00000483860
ENST00000562918
Show » 181 19.7 Yes 0
ITGAX-004 ENSP00000454623
ENST00000562522
H3BN02
Show all »
Show » Show » 1169 128.5 Yes 1