MEP1B

GENE INFORMATION

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Gene name

MEP1B

Synonyms

Description

Meprin A, beta (HGNC Symbol)

Entrez gene summary

Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011]

Chromosome

18

Cytoband

q12.1

Chromosome location (bp)

32185069 - 32220404

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000141434 (version 78.38)

Entrez gene

4225

UniProt

Q16820 (UniProt - Evidence at protein level)

neXtProt

NX_Q16820

Antibodypedia

MEP1B antibodies
 

PROTEIN VIEW

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MEP1B-001
 
MEP1B-002
 
MEP1B-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MEP1B-001 ENSP00000269202
ENST00000269202
Q16820
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Show » Show » 701 79.6 Yes 1
MEP1B-002 ENSP00000463280
ENST00000581447
J3QKX5
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Show » Show » 700 79.4 Yes 1
MEP1B-004 ENSP00000462038
ENST00000581184
J3KRK1
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Show » Show » 114 13 No 0