Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)

GO:0000060 [protein import into nucleus, translocation]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000733 [DNA strand renaturation]
GO:0000785 [chromatin]
GO:0000790 [nuclear chromatin]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0001701 [in utero embryonic development]
GO:0001756 [somitogenesis]
GO:0001836 [release of cytochrome c from mitochondria]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0002309 [T cell proliferation involved in immune response]
GO:0002326 [B cell lineage commitment]
GO:0002360 [T cell lineage commitment]
GO:0002931 [response to ischemia]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006302 [double-strand break repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0006979 [response to oxidative stress]
GO:0006983 [ER overload response]
GO:0007050 [cell cycle arrest]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007369 [gastrulation]
GO:0007406 [negative regulation of neuroblast proliferation]
GO:0007417 [central nervous system development]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008156 [negative regulation of DNA replication]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0009303 [rRNA transcription]
GO:0009411 [response to UV]
GO:0009651 [response to salt stress]
GO:0009792 [embryo development ending in birth or egg hatching]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0010666 [positive regulation of cardiac muscle cell apoptotic process]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0021549 [cerebellum development]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031497 [chromatin assembly]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0033077 [T cell differentiation in thymus]
GO:0034103 [regulation of tissue remodeling]
GO:0034613 [cellular protein localization]
GO:0034644 [cellular response to UV]
GO:0035033 [histone deacetylase regulator activity]
GO:0035035 [histone acetyltransferase binding]
GO:0035264 [multicellular organism growth]
GO:0035690 [cellular response to drug]
GO:0035794 [positive regulation of mitochondrial membrane permeability]
GO:0042127 [regulation of cell proliferation]
GO:0042149 [cellular response to glucose starvation]
GO:0042493 [response to drug]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043504 [mitochondrial DNA repair]
GO:0043523 [regulation of neuron apoptotic process]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046677 [response to antibiotic]
GO:0046872 [metal ion binding]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0048568 [embryonic organ development]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051087 [chaperone binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051262 [protein tetramerization]
GO:0051276 [chromosome organization]
GO:0051402 [neuron apoptotic process]
GO:0051721 [protein phosphatase 2A binding]
GO:0051726 [regulation of cell cycle]
GO:0070243 [regulation of thymocyte apoptotic process]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0070266 [necroptotic process]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0071850 [mitotic cell cycle arrest]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090343 [positive regulation of cell aging]
GO:0090399 [replicative senescence]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097252 [oligodendrocyte apoptotic process]
GO:0097371 [MDM2/MDM4 family protein binding]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:1901525 [negative regulation of macromitophagy]
GO:1902108 [regulation of mitochondrial membrane permeability involved in apoptotic process]
GO:1902253 [regulation of intrinsic apoptotic signaling pathway by p53 class mediator]
GO:2000269 [regulation of fibroblast apoptotic process]
GO:2000378 [negative regulation of reactive oxygen species metabolic process]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]

Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)

GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005515 [protein binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0044212 [transcription regulatory region DNA binding]

Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)

GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000733 [DNA strand renaturation]
GO:0000785 [chromatin]
GO:0000790 [nuclear chromatin]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0006983 [ER overload response]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031497 [chromatin assembly]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0034613 [cellular protein localization]
GO:0034644 [cellular response to UV]
GO:0035035 [histone acetyltransferase binding]
GO:0035690 [cellular response to drug]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046677 [response to antibiotic]
GO:0046872 [metal ion binding]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051087 [chaperone binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051262 [protein tetramerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090399 [replicative senescence]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097252 [oligodendrocyte apoptotic process]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]

Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)

GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000733 [DNA strand renaturation]
GO:0000785 [chromatin]
GO:0000790 [nuclear chromatin]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0006983 [ER overload response]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031497 [chromatin assembly]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0034613 [cellular protein localization]
GO:0034644 [cellular response to UV]
GO:0035035 [histone acetyltransferase binding]
GO:0035690 [cellular response to drug]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046677 [response to antibiotic]
GO:0046872 [metal ion binding]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051087 [chaperone binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051262 [protein tetramerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090399 [replicative senescence]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097252 [oligodendrocyte apoptotic process]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]

Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)

GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0044212 [transcription regulatory region DNA binding]
GO:0046872 [metal ion binding]

Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)

GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0044212 [transcription regulatory region DNA binding]
GO:0046872 [metal ion binding]

Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)

GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0007049 [cell cycle]
GO:0044212 [transcription regulatory region DNA binding]
GO:0046872 [metal ion binding]

Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)

GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]

Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)

GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000733 [DNA strand renaturation]
GO:0000785 [chromatin]
GO:0000790 [nuclear chromatin]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0006983 [ER overload response]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031497 [chromatin assembly]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0034613 [cellular protein localization]
GO:0034644 [cellular response to UV]
GO:0035035 [histone acetyltransferase binding]
GO:0035690 [cellular response to drug]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046677 [response to antibiotic]
GO:0046872 [metal ion binding]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051087 [chaperone binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051262 [protein tetramerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090399 [replicative senescence]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097252 [oligodendrocyte apoptotic process]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]

Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)

GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0044212 [transcription regulatory region DNA binding]

Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)

GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0044212 [transcription regulatory region DNA binding]

Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)

GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000733 [DNA strand renaturation]
GO:0000785 [chromatin]
GO:0000790 [nuclear chromatin]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0006983 [ER overload response]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031497 [chromatin assembly]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0034613 [cellular protein localization]
GO:0034644 [cellular response to UV]
GO:0035035 [histone acetyltransferase binding]
GO:0035690 [cellular response to drug]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046677 [response to antibiotic]
GO:0046872 [metal ion binding]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051087 [chaperone binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051262 [protein tetramerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090399 [replicative senescence]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097252 [oligodendrocyte apoptotic process]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]

Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Transcription factors
   Immunoglobulin fold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
   COSMIC Translocations
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)

GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000733 [DNA strand renaturation]
GO:0000785 [chromatin]
GO:0000790 [nuclear chromatin]
GO:0001085 [RNA polymerase II transcription factor binding]
GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0002020 [protease binding]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003684 [damaged DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005507 [copper ion binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005669 [transcription factor TFIID complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0005829 [cytosol]
GO:0006284 [base-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006461 [protein complex assembly]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0006983 [ER overload response]
GO:0007050 [cell cycle arrest]
GO:0007219 [Notch signaling pathway]
GO:0007265 [Ras protein signal transduction]
GO:0007275 [multicellular organismal development]
GO:0007569 [cell aging]
GO:0007596 [blood coagulation]
GO:0008104 [protein localization]
GO:0008134 [transcription factor binding]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008340 [determination of adult lifespan]
GO:0010165 [response to X-ray]
GO:0010332 [response to gamma radiation]
GO:0016032 [viral process]
GO:0016363 [nuclear matrix]
GO:0016604 [nuclear body]
GO:0016605 [PML body]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019903 [protein phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030308 [negative regulation of cell growth]
GO:0030330 [DNA damage response, signal transduction by p53 class mediator]
GO:0030971 [receptor tyrosine kinase binding]
GO:0031065 [positive regulation of histone deacetylation]
GO:0031497 [chromatin assembly]
GO:0031571 [mitotic G1 DNA damage checkpoint]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032461 [positive regulation of protein oligomerization]
GO:0034613 [cellular protein localization]
GO:0034644 [cellular response to UV]
GO:0035035 [histone acetyltransferase binding]
GO:0035690 [cellular response to drug]
GO:0042149 [cellular response to glucose starvation]
GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046677 [response to antibiotic]
GO:0046872 [metal ion binding]
GO:0046902 [regulation of mitochondrial membrane permeability]
GO:0046982 [protein heterodimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0051087 [chaperone binding]
GO:0051097 [negative regulation of helicase activity]
GO:0051262 [protein tetramerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0070245 [positive regulation of thymocyte apoptotic process]
GO:0071158 [positive regulation of cell cycle arrest]
GO:0071456 [cellular response to hypoxia]
GO:0071479 [cellular response to ionizing radiation]
GO:0072332 [intrinsic apoptotic signaling pathway by p53 class mediator]
GO:0090200 [positive regulation of release of cytochrome c from mitochondria]
GO:0090399 [replicative senescence]
GO:0090403 [oxidative stress-induced premature senescence]
GO:0097193 [intrinsic apoptotic signaling pathway]
GO:0097252 [oligodendrocyte apoptotic process]
GO:1900740 [positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway]
GO:2000379 [positive regulation of reactive oxygen species metabolic process]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]