BRD4 - Gene info - The Human Protein Atlas

Gene name

BRD4 (HGNC Symbol)

Synonyms

CAP, HUNK1, HUNKI, MCAP

Description

Bromodomain containing 4 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

p13.12

Chromosome location (bp)

15235519 - 15332545

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000141867 (version 78.38)

Entrez gene

23476

UniProt

O60885 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

BRD4-001

ENSP00000263377
ENST00000263377

O60885
Show all » « Hide

O60885 [Direct mapping]
Bromodomain-containing protein 4
M0QZD9 [Target identity:41%; Query identity:100%]
Bromodomain-containing protein 4 {ECO:0000313|Ensembl:ENSP00000470481}
Q96HN0 [Target identity:13%; Query identity:100%]
Similar to bromodomain-containing 4 {ECO:0000313|EMBL:AAH08354.1}
M0R0H4 [Target identity:7%; Query identity:100%]
Bromodomain-containing protein 4 {ECO:0000313|Ensembl:ENSP00000471240}

Show » « Hide

Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000790 [nuclear chromatin]
GO:0000794 [condensed nuclear chromosome]
GO:0001833 [inner cell mass cell proliferation]
GO:0002039 [p53 binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007059 [chromosome segregation]
GO:0008024 [positive transcription elongation factor complex b]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0016032 [viral process]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043388 [positive regulation of DNA binding]
GO:0043983 [histone H4-K12 acetylation]
GO:0044154 [histone H3-K14 acetylation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050727 [regulation of inflammatory response]
GO:0070577 [lysine-acetylated histone binding]
GO:1901407 [regulation of phosphorylation of RNA polymerase II C-terminal domain]
GO:2000002 [negative regulation of DNA damage checkpoint]

1362

152.2

BRD4-002

ENSP00000360901
ENST00000371835

O60885
Show all » « Hide

O60885 [Direct mapping]
Bromodomain-containing protein 4
M0QZD9 [Target identity:79%; Query identity:100%]
Bromodomain-containing protein 4 {ECO:0000313|Ensembl:ENSP00000470481}
M0R0H4 [Target identity:14%; Query identity:100%]
Bromodomain-containing protein 4 {ECO:0000313|Ensembl:ENSP00000471240}

Show » « Hide

GO:0000083 [regulation of transcription involved in G1/S transition of mitotic cell cycle]
GO:0000794 [condensed nuclear chromosome]
GO:0002039 [p53 binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0010971 [positive regulation of G2/M transition of mitotic cell cycle]
GO:0016032 [viral process]
GO:0032968 [positive regulation of transcription elongation from RNA polymerase II promoter]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050727 [regulation of inflammatory response]
GO:0070577 [lysine-acetylated histone binding]
GO:1901407 [regulation of phosphorylation of RNA polymerase II C-terminal domain]
GO:2000002 [negative regulation of DNA damage checkpoint]

722

80.5

BRD4-003

ENSP00000353112
ENST00000360016

O60885
Show all » « Hide

O60885 [Direct mapping]
Bromodomain-containing protein 4
A0A024R7H8 [Target identity:100%; Query identity:100%]
Bromodomain containing 4, isoform CRA_b {ECO:0000313|EMBL:EAW84471.1}
M0QZD9 [Target identity:72%; Query identity:100%]
Bromodomain-containing protein 4 {ECO:0000313|Ensembl:ENSP00000470481}
M0R0H4 [Target identity:13%; Query identity:100%]
Bromodomain-containing protein 4 {ECO:0000313|Ensembl:ENSP00000471240}

Show » « Hide

794

88.3

BRD4-004

ENSP00000470481
ENST00000594841

M0QZD9
Show all » « Hide

M0QZD9 [Target identity:100%; Query identity:100%]
Bromodomain-containing protein 4 {ECO:0000313|Ensembl:ENSP00000470481}
M0R0H4 [Target identity:18%; Query identity:100%]
Bromodomain-containing protein 4 {ECO:0000313|Ensembl:ENSP00000471240}

Show » « Hide

Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0005515 [protein binding]

572

63.8

BRD4-008

ENSP00000471240
ENST00000601941

M0R0H4
Show all » « Hide

M0R0H4 [Target identity:100%; Query identity:100%]
Bromodomain-containing protein 4 {ECO:0000313|Ensembl:ENSP00000471240}

Show » « Hide

GO:0005515 [protein binding]

105

11.7

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.