PRKACB - Gene info - The Human Protein Atlas

PRKACB

premium

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

? »

Gene name	PRKACB (HGNC Symbol)
Synonyms	PKACb
Description	Protein kinase, cAMP-dependent, catalytic, beta (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]
Chromosome	1
Cytoband	p31.1
Chromosome location (bp)	84078062 - 84238498
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000142875 (version 78.38)
Entrez gene	5567
UniProt	P22694 (UniProt - Evidence at protein level)
neXtProt	NX_P22694
Antibodypedia	PRKACB antibodies

PROTEIN VIEW

? »

PRKACB-001		PRKACB-002		PRKACB-003		PRKACB-004		PRKACB-005		PRKACB-007		PRKACB-008		PRKACB-009		PRKACB-010		PRKACB-011		PRKACB-012		PRKACB-013		PRKACB-201		PRKACB-202		PRKACB-203		PRKACB-204		PRKACB-205

PROTEIN INFORMATION

? »

Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
PRKACB-001	ENSP00000359723 ENST00000370689	P22694 Show all » « Hide P22694 [Direct mapping] cAMP-dependent protein kinase catalytic subunit beta B2RB89 [Target identity:100%; Query identity:100%] Protein kinase, cAMP-dependent, catalytic, beta, isoform CRA_a {ECO:0000313\|EMBL:EAW73247.1}; cAMP-dependent protein kinase catalytic subunit beta isoform 2 {ECO:0000313\|EMBL:BAG70053.1}; cDNA, FLJ95374, Homo sapiens protein kinase, cAMP-dependent, catalytic, beta(PRKACB), transcript variant 2, mRNA {ECO:0000313\|EMBL:BAG37136.1}	Show » « Hide Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004691 [cAMP-dependent protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005952 [cAMP-dependent protein kinase complex] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006112 [energy reserve metabolic process] GO:0006468 [protein phosphorylation] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0019433 [triglyceride catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0035556 [intracellular signal transduction] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0070062 [extracellular vesicular exosome] GO:0071377 [cellular response to glucagon stimulus]	351	40.6	No	0
PRKACB-002	ENSP00000359722 ENST00000370688	P22694 Show all » « Hide P22694 [Direct mapping] cAMP-dependent protein kinase catalytic subunit beta	Show » « Hide Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004691 [cAMP-dependent protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005952 [cAMP-dependent protein kinase complex] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006112 [energy reserve metabolic process] GO:0006468 [protein phosphorylation] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0019433 [triglyceride catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0035556 [intracellular signal transduction] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0070062 [extracellular vesicular exosome] GO:0071377 [cellular response to glucagon stimulus]	257	29.7	No	0
PRKACB-003	ENSP00000359714 ENST00000370680	B1APG3 Show all » « Hide B1APG3 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase catalytic subunit beta {ECO:0000313\|Ensembl:ENSP00000359714}	Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	264	30.5	No	0
PRKACB-004	ENSP00000359719 ENST00000370685	P22694 Show all » « Hide P22694 [Direct mapping] cAMP-dependent protein kinase catalytic subunit beta	Show » « Hide Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000287 [magnesium ion binding] GO:0001843 [neural tube closure] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004691 [cAMP-dependent protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005952 [cAMP-dependent protein kinase complex] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006112 [energy reserve metabolic process] GO:0006468 [protein phosphorylation] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0019433 [triglyceride catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0035556 [intracellular signal transduction] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048471 [perinuclear region of cytoplasm] GO:0050796 [regulation of insulin secretion] GO:0051447 [negative regulation of meiotic cell cycle] GO:0055085 [transmembrane transport] GO:0070062 [extracellular vesicular exosome] GO:0070613 [regulation of protein processing] GO:0071377 [cellular response to glucagon stimulus] GO:0097338 [response to clozapine] GO:0097546 [ciliary base] GO:1901621 [negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning]	398	46.2	No	0
PRKACB-005	ENSP00000378315 ENST00000394839	P22694 Show all » « Hide P22694 [Direct mapping] cAMP-dependent protein kinase catalytic subunit beta	Show » « Hide Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004691 [cAMP-dependent protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005952 [cAMP-dependent protein kinase complex] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006112 [energy reserve metabolic process] GO:0006468 [protein phosphorylation] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0019433 [triglyceride catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0035556 [intracellular signal transduction] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0070062 [extracellular vesicular exosome] GO:0071377 [cellular response to glucagon stimulus]	321	37	No	0
PRKACB-007	ENSP00000401252 ENST00000446538	B1APF6 Show all » « Hide B1APF6 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase catalytic subunit beta {ECO:0000313\|Ensembl:ENSP00000401252}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	175	20.3	No	0
PRKACB-008	ENSP00000359718 ENST00000370684	B1APF9 Show all » « Hide B1APF9 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase catalytic subunit beta {ECO:0000313\|Ensembl:ENSP00000359718}	Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	245	28.5	No	0
PRKACB-009	ENSP00000390906 ENST00000436133	B1APF7 Show all » « Hide B1APF7 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase catalytic subunit beta {ECO:0000313\|Ensembl:ENSP00000390906}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	186	21.6	No	0
PRKACB-010	ENSP00000392275 ENST00000432111	B1APF8 Show all » « Hide B1APF8 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase catalytic subunit beta {ECO:0000313\|Ensembl:ENSP00000392275}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	214	24.9	No	0
PRKACB-011	ENSP00000393654 ENST00000450730	B1APG0 Show all » « Hide B1APG0 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase catalytic subunit beta {ECO:0000313\|Ensembl:ENSP00000393654}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	206	23.9	No	0
PRKACB-012	ENSP00000397175 ENST00000413538	B1APG2 Show all » « Hide B1APG2 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase catalytic subunit beta {ECO:0000313\|Ensembl:ENSP00000397175}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	209	24.3	No	0
PRKACB-013	ENSP00000399326 ENST00000417530	B1APG1 Show all » « Hide B1APG1 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase catalytic subunit beta {ECO:0000313\|Ensembl:ENSP00000399326}	Show » « Hide Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	197	23.1	No	0
PRKACB-201	ENSP00000359716 ENST00000370682	B1APF7 Show all » « Hide B1APF7 [Target identity:52%; Query identity:100%] cAMP-dependent protein kinase catalytic subunit beta {ECO:0000313\|Ensembl:ENSP00000390906}	Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	355	41	No	0
PRKACB-202	ENSP00000378314 ENST00000394838		Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	357	41.3	No	0
PRKACB-203	ENSP00000479339 ENST00000610457		Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	338	39.2	No	0
PRKACB-204	ENSP00000481980 ENST00000610703	P22694 Show all » « Hide P22694 [Direct mapping] cAMP-dependent protein kinase catalytic subunit beta	Show » « Hide Enzymes ENZYME proteins Transferases Kinases AGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004691 [cAMP-dependent protein kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0005952 [cAMP-dependent protein kinase complex] GO:0005975 [carbohydrate metabolic process] GO:0006006 [glucose metabolic process] GO:0006094 [gluconeogenesis] GO:0006112 [energy reserve metabolic process] GO:0006468 [protein phosphorylation] GO:0006833 [water transport] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007202 [activation of phospholipase C activity] GO:0007268 [synaptic transmission] GO:0007596 [blood coagulation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0016772 [transferase activity, transferring phosphorus-containing groups] GO:0019433 [triglyceride catabolic process] GO:0031625 [ubiquitin protein ligase binding] GO:0034199 [activation of protein kinase A activity] GO:0035556 [intracellular signal transduction] GO:0044281 [small molecule metabolic process] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050796 [regulation of insulin secretion] GO:0055085 [transmembrane transport] GO:0070062 [extracellular vesicular exosome] GO:0071377 [cellular response to glucagon stimulus]	339	39.5	No	0
PRKACB-205	ENSP00000479722 ENST00000614872		Show » « Hide MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004713 [protein tyrosine kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0016772 [transferase activity, transferring phosphorus-containing groups]	357	41.3	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.