NR1I3 - Gene info - The Human Protein Atlas

NR1I3

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	NR1I3 (HGNC Symbol)
Synonyms	CAR, CAR1, MB67
Description	Nuclear receptor subfamily 1, group I, member 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. The protein binds to DNA as a monomer or a heterodimer with the retinoid X receptor and regulates the transcription of target genes involved in drug metabolism and bilirubin clearance, such as cytochrome P450 family members. Unlike most nuclear receptors, this transcriptional regulator is constitutively active in the absence of ligand but is regulated by both agonists and inverse agonists. Ligand binding results in translocation of this protein to the nucleus, where it activates or represses target gene transcription. These ligands include bilirubin, a variety of foreign compounds, steroid hormones, and prescription drugs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	161229666 - 161238302
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000143257 (version 78.38)
Entrez gene	9970
UniProt	Q14994 (UniProt - Evidence at protein level)
neXtProt	NX_Q14994
Antibodypedia	NR1I3 antibodies

PROTEIN VIEW

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NR1I3-001		NR1I3-002		NR1I3-008		NR1I3-009		NR1I3-011		NR1I3-012		NR1I3-013		NR1I3-014		NR1I3-015		NR1I3-016		NR1I3-019		NR1I3-021		NR1I3-024		NR1I3-025		NR1I3-026		NR1I3-027		NR1I3-029		NR1I3-030		NR1I3-031		NR1I3-032		NR1I3-033		NR1I3-036		NR1I3-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)
NR1I3-001	ENSP00000356962 ENST00000367983	Q14994 Show all » « Hide Q14994 [Direct mapping] Nuclear receptor subfamily 1 group I member 3 D6REZ7 [Target identity:78%; Query identity:100%] Nuclear receptor subfamily 1 group I member 3 {ECO:0000313\|Ensembl:ENSP00000421588}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cytoskeleton related proteins	Show » « Hide GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0004882 [androgen receptor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0030521 [androgen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	348	39.6	No
NR1I3-002	ENSP00000356961 ENST00000367982	Q14994 Show all » « Hide Q14994 [Direct mapping] Nuclear receptor subfamily 1 group I member 3	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cytoskeleton related proteins	Show » « Hide GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0004882 [androgen receptor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0030521 [androgen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	352	39.9	No
NR1I3-008	ENSP00000427034 ENST00000515452	B7Z8R7 Show all » « Hide B7Z8R7 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 1 group I member 3 {ECO:0000313\|Ensembl:ENSP00000427034}; cDNA FLJ56764, highly similar to Orphan nuclear receptor NR1I3 {ECO:0000313\|EMBL:BAH14053.1}; cDNA, FLJ79107, highly similar to Orphan nuclear receptor NR1I3 {ECO:0000313\|EMBL:BAH14579.1}	Show » « Hide Predicted intracellular proteins	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding]	238	26.8	No
NR1I3-009	ENSP00000423089 ENST00000506209	E9PCF2 Show all » « Hide E9PCF2 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 1 group I member 3 {ECO:0000313\|Ensembl:ENSP00000423089}	Show » « Hide Predicted intracellular proteins	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding]	297	34	No
NR1I3-011	ENSP00000356963 ENST00000367984	Q14994 Show all » « Hide Q14994 [Direct mapping] Nuclear receptor subfamily 1 group I member 3	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cytoskeleton related proteins	Show » « Hide GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0004882 [androgen receptor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0030521 [androgen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	309	35	No
NR1I3-012	ENSP00000356965 ENST00000367985	Q14994 Show all » « Hide Q14994 [Direct mapping] Nuclear receptor subfamily 1 group I member 3	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cytoskeleton related proteins	Show » « Hide GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0004882 [androgen receptor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0030521 [androgen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	314	35.6	No
NR1I3-013	ENSP00000422982 ENST00000508387	Q6GZ70 Show all » « Hide Q6GZ70 [Target identity:100%; Query identity:100%] Constitutive androstane receptor SV19 {ECO:0000313\|EMBL:AAT47177.1}; Constitutive androstane receptor SV20 {ECO:0000313\|EMBL:AAT47178.1}; Nuclear receptor subfamily 1 group I member 3 {ECO:0000313\|Ensembl:ENSP00000422982}	Show » « Hide Nuclear receptors Predicted intracellular proteins	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding]	118	13.5	No
NR1I3-014	ENSP00000424345 ENST00000504010	Q14994 Show all » « Hide Q14994 [Direct mapping] Nuclear receptor subfamily 1 group I member 3	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cytoskeleton related proteins	Show » « Hide GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0004882 [androgen receptor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0030521 [androgen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	280	31.9	No
NR1I3-015	ENSP00000427175 ENST00000511676	Q14994 Show all » « Hide Q14994 [Direct mapping] Nuclear receptor subfamily 1 group I member 3 D6REZ7 [Target identity:85%; Query identity:100%] Nuclear receptor subfamily 1 group I member 3 {ECO:0000313\|Ensembl:ENSP00000421588}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cytoskeleton related proteins	Show » « Hide GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0004882 [androgen receptor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0030521 [androgen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	319	36.4	No
NR1I3-016	ENSP00000421374 ENST00000502985	Q6GZ72 Show all » « Hide Q6GZ72 [Target identity:100%; Query identity:100%] Constitutive androstane receptor SV17 {ECO:0000313\|EMBL:AAT47175.1}; Constitutive androstane receptor SV18 {ECO:0000313\|EMBL:AAT47176.1}; Nuclear receptor subfamily 1 group I member 3 {ECO:0000313\|Ensembl:ENSP00000421374}	Show » « Hide Nuclear receptors Predicted intracellular proteins	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043565 [sequence-specific DNA binding]	147	16.6	No
NR1I3-019	ENSP00000356960 ENST00000367981	Q14994 Show all » « Hide Q14994 [Direct mapping] Nuclear receptor subfamily 1 group I member 3	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cytoskeleton related proteins	Show » « Hide GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0004882 [androgen receptor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0030521 [androgen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	324	37	No
NR1I3-021	ENSP00000421588 ENST00000515621	D6REZ7 Show all » « Hide D6REZ7 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 1 group I member 3 {ECO:0000313\|Ensembl:ENSP00000421588}	Show » « Hide Phobius predicted secreted proteins Predicted intracellular proteins	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway]	273	31.4	No
NR1I3-024	ENSP00000425417 ENST00000512372	Q14994 Show all » « Hide Q14994 [Direct mapping] Nuclear receptor subfamily 1 group I member 3	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cytoskeleton related proteins	Show » « Hide GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0004882 [androgen receptor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0030521 [androgen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	267	30.3	No
NR1I3-025	ENSP00000407446 ENST00000437437	Q14994 Show all » « Hide Q14994 [Direct mapping] Nuclear receptor subfamily 1 group I member 3	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cytoskeleton related proteins	Show » « Hide GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0004882 [androgen receptor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0030521 [androgen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	306	34.8	No
NR1I3-026	ENSP00000426292 ENST00000511944	Q6GZ72 Show all » « Hide Q6GZ72 [Target identity:100%; Query identity:100%] Constitutive androstane receptor SV17 {ECO:0000313\|EMBL:AAT47175.1}; Constitutive androstane receptor SV18 {ECO:0000313\|EMBL:AAT47176.1}; Nuclear receptor subfamily 1 group I member 3 {ECO:0000313\|Ensembl:ENSP00000421374}	Show » « Hide Nuclear receptors Predicted intracellular proteins	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043565 [sequence-specific DNA binding]	147	16.6	No
NR1I3-027	ENSP00000427600 ENST00000511748	Q6GZ70 Show all » « Hide Q6GZ70 [Target identity:100%; Query identity:100%] Constitutive androstane receptor SV19 {ECO:0000313\|EMBL:AAT47177.1}; Constitutive androstane receptor SV20 {ECO:0000313\|EMBL:AAT47178.1}; Nuclear receptor subfamily 1 group I member 3 {ECO:0000313\|Ensembl:ENSP00000422982}	Show » « Hide Nuclear receptors Predicted intracellular proteins	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding]	118	13.5	No
NR1I3-029	ENSP00000406493 ENST00000442691	Q14994 Show all » « Hide Q14994 [Direct mapping] Nuclear receptor subfamily 1 group I member 3	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cytoskeleton related proteins	Show » « Hide GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0004882 [androgen receptor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0030521 [androgen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	339	38.3	No
NR1I3-030	ENSP00000399361 ENST00000412844	Q14994 Show all » « Hide Q14994 [Direct mapping] Nuclear receptor subfamily 1 group I member 3	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cytoskeleton related proteins	Show » « Hide GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0004882 [androgen receptor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0030521 [androgen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	315	35.7	No
NR1I3-031	ENSP00000412672 ENST00000428574	Q14994 Show all » « Hide Q14994 [Direct mapping] Nuclear receptor subfamily 1 group I member 3	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cytoskeleton related proteins	Show » « Hide GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0004882 [androgen receptor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0030521 [androgen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	340	38.5	No
NR1I3-032	ENSP00000424934 ENST00000505005	Q14994 Show all » « Hide Q14994 [Direct mapping] Nuclear receptor subfamily 1 group I member 3	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cytoskeleton related proteins	Show » « Hide GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0004882 [androgen receptor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0030521 [androgen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	296	33.4	No
NR1I3-033	ENSP00000423666 ENST00000508740	Q14994 Show all » « Hide Q14994 [Direct mapping] Nuclear receptor subfamily 1 group I member 3	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cytoskeleton related proteins	Show » « Hide GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0004882 [androgen receptor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0030521 [androgen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	311	35.3	No
NR1I3-036	ENSP00000356958 ENST00000367979	Q14994 Show all » « Hide Q14994 [Direct mapping] Nuclear receptor subfamily 1 group I member 3 F1DAL4 [Target identity:98%; Query identity:100%] Constitutive androstane nuclear receptor {ECO:0000313\|EMBL:ADZ17385.1}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cytoskeleton related proteins	Show » « Hide GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0004882 [androgen receptor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0030521 [androgen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	357	40.5	No
NR1I3-201	ENSP00000356959 ENST00000367980	Q14994 Show all » « Hide Q14994 [Direct mapping] Nuclear receptor subfamily 1 group I member 3 F1DAL4 [Target identity:98%; Query identity:100%] Constitutive androstane nuclear receptor {ECO:0000313\|EMBL:ADZ17385.1}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cytoskeleton related proteins	Show » « Hide GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity] GO:0004882 [androgen receptor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005856 [cytoskeleton] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0030521 [androgen receptor signaling pathway] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	357	40.5	No

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.