PKP4

GENE INFORMATION

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Gene name

PKP4 (HGNC Symbol)

Synonyms

p0071

Description

Plakophilin 4 (HGNC Symbol)

Entrez gene summary

Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants have been found for this gene, but the full-length nature of only two of them have been described so far. These two variants encode distinct isoforms. [provided by RefSeq, Jul 2008]

Chromosome

2

Cytoband

q24.1

Chromosome location (bp)

158456964 - 158682879

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000144283 (version 78.38)

Entrez gene

8502

UniProt

Q99569 (UniProt - Evidence at protein level)

neXtProt

NX_Q99569

Antibodypedia

PKP4 antibodies
 

PROTEIN VIEW

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PKP4-001
 
PKP4-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PKP4-001 ENSP00000374407
ENST00000389757
Q99569
Show all »
Show » Show » 1149 127.1 No 0
PKP4-002 ENSP00000374409
ENST00000389759
Q99569
Show all »
Show » Show » 1192 131.9 No 0