SLC4A10

GENE INFORMATION

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Gene name

SLC4A10 (HGNC Symbol)

Synonyms

NBCn2, NCBE

Description

Solute carrier family 4, sodium bicarbonate transporter, member 10 (HGNC Symbol)

Entrez gene summary

This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

Chromosome

2

Cytoband

q24.2

Chromosome location (bp)

161424332 - 161985282

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000144290 (version 78.38)

Entrez gene

57282

UniProt

Q6U841 (UniProt - Evidence at transcript level)

neXtProt

NX_Q6U841

Antibodypedia

SLC4A10 antibodies
 

PROTEIN VIEW

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SLC4A10-001
 
SLC4A10-004
 
SLC4A10-009
 
SLC4A10-010
 
SLC4A10-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SLC4A10-001 ENSP00000395797
ENST00000415876
Q6U841
Show all »
Show » Show » 1088 122.6 No >9
SLC4A10-004 ENSP00000393066
ENST00000446997
Q6U841
Show all »
Show » Show » 1118 125.9 No >9
SLC4A10-009 ENSP00000272716
ENST00000272716
C9J240
Show all »
Show » Show » 1106 124.7 No >9
SLC4A10-010 ENSP00000404486
ENST00000421911
E7EW28
Show all »
Show » Show » 1054 118.8 No >9
SLC4A10-201 ENSP00000364664
ENST00000375514
Q6U841
Show all »
Show » Show » 1099 123.8 No >9