CHRNA6

GENE INFORMATION

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Gene name

CHRNA6

Synonyms

Description

Cholinergic receptor, nicotinic, alpha 6 (neuronal) (HGNC Symbol)

Entrez gene summary

This gene encodes an alpha subunit of neuronal nicotinic acetylcholine receptors. These receptors consist of five subunits and function as ion channels involved in neurotransmission. The encoded protein is a subunit of neuronal nicotinic acetylcholine receptors that mediate dopaminergic neurotransmission and are activated by acetylcholine and exogenous nicotine. Alternatively spliced transcript variants have been observed for this gene. Single nucleotide polymorphisms in this gene have been associated with both nicotine and alcohol dependence. [provided by RefSeq, Dec 2010]

Chromosome

8

Cytoband

p11.21

Chromosome location (bp)

42752620 - 42796392

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000147434 (version 78.38)

Entrez gene

8973

UniProt

Q15825 (UniProt - Evidence at transcript level)

neXtProt

NX_Q15825

Antibodypedia

CHRNA6 antibodies
 

PROTEIN VIEW

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CHRNA6-001
 
CHRNA6-004
 
CHRNA6-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CHRNA6-001 ENSP00000276410
ENST00000276410
Q15825
Show all »
Show » Show » 494 56.9 Yes 4
CHRNA6-004 ENSP00000433871
ENST00000534622
Q15825
Show all »
Show » Show » 479 55 Yes 4
CHRNA6-005 ENSP00000434659
ENST00000533810
E9PP97
Show all »
Show » Show » 111 13.1 No 0