NR6A1 - Gene info - The Human Protein Atlas

Gene name

NR6A1 (HGNC Symbol)

Synonyms

CT150, GCNF, GCNF1, RTR

Description

Nuclear receptor subfamily 6, group A, member 1 (HGNC Symbol)

Entrez gene summary

This gene encodes an orphan nuclear receptor which is a member of the nuclear hormone receptor family. Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2013]

Chromosome

Cytoband

q33.3

Chromosome location (bp)

124517275 - 124771310

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000148200 (version 78.38)

Entrez gene

2649

UniProt

Q15406 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NR6A1-001

ENSP00000420267
ENST00000487099

Q15406
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Q15406 [Direct mapping]
Nuclear receptor subfamily 6 group A member 1
F1D8S0 [Target identity:100%; Query identity:100%]
Germ cell nuclear factor variant 1 {ECO:0000313|EMBL:ADZ17369.1}; Nuclear receptor subfamily 6, group A, member 1, isoform CRA_b {ECO:0000313|EMBL:EAW87594.1}

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Nuclear receptors
Predicted intracellular proteins
Transcription factors
Zinc-coordinating DNA-binding domains

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007276 [gamete generation]
GO:0007283 [spermatogenesis]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]

480

54.4

NR6A1-002

ENSP00000413701
ENST00000416460

Q15406
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Q15406 [Direct mapping]
Nuclear receptor subfamily 6 group A member 1

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Nuclear receptors
Predicted intracellular proteins
Transcription factors
Zinc-coordinating DNA-binding domains

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0004879 [ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007276 [gamete generation]
GO:0007283 [spermatogenesis]
GO:0008270 [zinc ion binding]
GO:0008283 [cell proliferation]
GO:0010467 [gene expression]
GO:0030522 [intracellular receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]

475

53.9

NR6A1-003

ENSP00000362686
ENST00000373584

Q15406
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Q15406 [Direct mapping]
Nuclear receptor subfamily 6 group A member 1
F1DAM1 [Target identity:100%; Query identity:100%]
Germ cell nuclear factor {ECO:0000313|EMBL:ADZ17392.1}; Nuclear receptor subfamily 6, group A, member 1, isoform CRA_a {ECO:0000313|EMBL:EAW87593.1}

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Nuclear receptors
Predicted intracellular proteins
Transcription factors
Zinc-coordinating DNA-binding domains

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476

NR6A1-004

ENSP00000341135
ENST00000344523

Q15406
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Q15406 [Direct mapping]
Nuclear receptor subfamily 6 group A member 1

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Nuclear receptors
Predicted intracellular proteins
Transcription factors
Zinc-coordinating DNA-binding domains

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479

54.3

NR6A1-005

ENSP00000420587
ENST00000475178

C9JDI9
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C9JDI9 [Target identity:99%; Query identity:100%]
Nuclear receptor subfamily 6 group A member 1 {ECO:0000313|Ensembl:ENSP00000420587}

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Predicted intracellular proteins

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GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003707 [steroid hormone receptor activity]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]

233

26.3

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.