RPL7A

GENE INFORMATION

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Gene name

RPL7A (HGNC Symbol)

Synonyms

L7A, SURF3, TRUP

Description

Ribosomal protein L7a (HGNC Symbol)

Entrez gene summary

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L7AE family of ribosomal proteins. It can interact with a subclass of nuclear hormone receptors, including thyroid hormone receptor, and inhibit their ability to transactivate by preventing their binding to their DNA response elements. This gene is included in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. It is co-transcribed with the U24, U36a, U36b, and U36c small nucleolar RNA genes, which are located in its second, fifth, fourth, and sixth introns, respectively. This gene rearranges with the trk proto-oncogene to form the chimeric oncogene trk-2h, which encodes an oncoprotein consisting of the N terminus of ribosomal protein L7a fused to the receptor tyrosine kinase domain of trk. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q34.2

Chromosome location (bp)

133348214 - 133351426

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000148303 (version 78.38)

Entrez gene

6130

UniProt

P62424 (UniProt - Evidence at protein level)

neXtProt

NX_P62424

Antibodypedia

RPL7A antibodies
 

PROTEIN VIEW

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RPL7A-004
 
RPL7A-005
 
RPL7A-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RPL7A-004 ENSP00000416638
ENST00000426651
Q5T8U3
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Show » Show » 191 21.5 No 0
RPL7A-005 ENSP00000361071
ENST00000315731
Q5T8U2
Show all »
Show » Show » 151 16.5 No 0
RPL7A-009 ENSP00000361076
ENST00000323345
P62424
Show all »
Show » Show » 266 30 No 0