NOTCH1

GENE INFORMATION

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Gene name

NOTCH1 (HGNC Symbol)

Synonyms

TAN1

Description

Notch 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development. [provided by RefSeq, Jul 2008]

Chromosome

9

Cytoband

q34.3

Chromosome location (bp)

136494444 - 136545862

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000148400 (version 78.38)

Entrez gene

4851

UniProt

P46531 (UniProt - Evidence at protein level)

neXtProt

NX_P46531

Antibodypedia

NOTCH1 antibodies
 

PROTEIN VIEW

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NOTCH1-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NOTCH1-001 ENSP00000277541
ENST00000277541
P46531
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