CAMK2G - Gene info - The Human Protein Atlas

Gene name

CAMK2G (HGNC Symbol)

Synonyms

CAMKG

Description

Calcium/calmodulin-dependent protein kinase II gamma (HGNC Symbol)

Entrez gene summary

The product of this gene is one of the four subunits of an enzyme which belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a gamma chain. Many alternatively spliced transcripts encoding different isoforms have been described but the full-length nature of all the variants has not been determined.[provided by RefSeq, Mar 2011]

Chromosome

Cytoband

q22.2

Chromosome location (bp)

73812501 - 73874591

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000148660 (version 78.38)

Entrez gene

818

UniProt

Q13555 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CAMK2G-001

ENSP00000315599
ENST00000322635

Q13555
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Q13555 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit gamma

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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004723 [calcium-dependent protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005954 [calcium- and calmodulin-dependent protein kinase complex]
GO:0006468 [protein phosphorylation]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0014733 [regulation of skeletal muscle adaptation]
GO:0016020 [membrane]
GO:0016311 [dephosphorylation]
GO:0016529 [sarcoplasmic reticulum]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030073 [insulin secretion]
GO:0030154 [cell differentiation]
GO:0030666 [endocytic vesicle membrane]
GO:0042803 [protein homodimerization activity]
GO:0051259 [protein oligomerization]
GO:0051924 [regulation of calcium ion transport]
GO:0060333 [interferon-gamma-mediated signaling pathway]

527

CAMK2G-002

ENSP00000277853
ENST00000351293

Q13555
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Q13555 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit gamma

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495

CAMK2G-003

ENSP00000393784
ENST00000433289

Q8WU40
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Q8WU40 [Target identity:100%; Query identity:100%]
CAMK2G protein {ECO:0000313|EMBL:AAH21269.2}; Calcium/calmodulin-dependent protein kinase type II subunit gamma {ECO:0000313|Ensembl:ENSP00000393784}

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

453

50.9

CAMK2G-004

ENSP00000361851
ENST00000372765

Q5SWX3
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Q5SWX3 [Target identity:100%; Query identity:100%]
Calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma, isoform CRA_n {ECO:0000313|EMBL:EAW54540.1}; Calcium/calmodulin-dependent protein kinase type II subunit gamma {ECO:0000313|Ensembl:ENSP00000361851}

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516

57.8

CAMK2G-005

ENSP00000307082
ENST00000305762

Q13555
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Q13555 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit gamma

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529

59.6

CAMK2G-010

ENSP00000405561
ENST00000441192

Q13280
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Q13280 [Target identity:83%; Query identity:100%]
Calcium/calmodulin-dependent protein kinase II {ECO:0000313|EMBL:AAB80847.1}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]

335

36.9

CAMK2G-201

ENSP00000319060
ENST00000322680

Q13555
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Q13555 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit gamma
Q13280 [Target identity:50%; Query identity:100%]
Calcium/calmodulin-dependent protein kinase II {ECO:0000313|EMBL:AAB80847.1}

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GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004723 [calcium-dependent protein serine/threonine phosphatase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005954 [calcium- and calmodulin-dependent protein kinase complex]
GO:0006468 [protein phosphorylation]
GO:0006816 [calcium ion transport]
GO:0007268 [synaptic transmission]
GO:0007399 [nervous system development]
GO:0014733 [regulation of skeletal muscle adaptation]
GO:0016020 [membrane]
GO:0016311 [dephosphorylation]
GO:0016529 [sarcoplasmic reticulum]
GO:0016772 [transferase activity, transferring phosphorus-containing groups]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0030073 [insulin secretion]
GO:0030154 [cell differentiation]
GO:0030666 [endocytic vesicle membrane]
GO:0042803 [protein homodimerization activity]
GO:0046777 [protein autophosphorylation]
GO:0051259 [protein oligomerization]
GO:0051924 [regulation of calcium ion transport]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:1901897 [regulation of relaxation of cardiac muscle]

556

62.2

CAMK2G-202

ENSP00000378243
ENST00000394762

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539

60.2

CAMK2G-203

ENSP00000410298
ENST00000423381

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558

62.6

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.