ADD3

GENE INFORMATION

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Gene name

ADD3 (HGNC Symbol)

Synonyms

ADDL

Description

Adducin 3 (gamma) (HGNC Symbol)

Entrez gene summary

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]

Chromosome

10

Cytoband

Chromosome location (bp)

109996368 - 110135565

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000148700 (version 78.38)

Entrez gene

120

UniProt

Q9UEY8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UEY8

Antibodypedia

ADD3 antibodies
 

PROTEIN VIEW

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ADD3-001
 
ADD3-002
 
ADD3-003
 
ADD3-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ADD3-001 ENSP00000348381
ENST00000356080
Q9UEY8
Show all »
Show » Show » 706 79.2 No 0
ADD3-002 ENSP00000277900
ENST00000277900
Q9UEY8
Show all »
Show » Show » 674 75.7 No 0
ADD3-003 ENSP00000353286
ENST00000360162
Q9UEY8
Show all »
Show » Show » 674 75.7 No 0
ADD3-201 ENSP00000480646
ENST00000611329
Show » 672 75.4 No 0