SYT8

GENE INFORMATION

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Gene name

SYT8 (HGNC Symbol)

Synonyms

DKFZp434K0322

Description

Synaptotagmin VIII (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the synaptotagmin protein family. Synaptotagmins are membrane proteins that are important in neurotransmission and hormone secretion, both of which involve regulated exocytosis. Expression of the encoded protein in human pancreatic islets has been connected to activity of the promoter for the insulin gene, on the same chromosome several hundred kilobases away (PMID: 21336277 and 22928559). This association would link response to gluclose to insulin secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

Chromosome

11

Cytoband

p15.5

Chromosome location (bp)

1828307 - 1837521

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000149043 (version 78.38)

Entrez gene

90019

UniProt

Q8NBV8 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8NBV8

Antibodypedia

SYT8 antibodies
 

PROTEIN VIEW

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SYT8-002
 
SYT8-004
 
SYT8-008
 
SYT8-010
 
SYT8-011
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SYT8-002 ENSP00000371394
ENST00000381968
Q8NBV8
Show all »
Show » Show » 401 44.1 No 1
SYT8-004 ENSP00000343691
ENST00000341958
A6NCR4
Show all »
Show » Show » 387 42.4 No 1
SYT8-008 ENSP00000371406
ENST00000381978
A6NCR4
Show all »
Show » Show » 400 43.8 No 1
SYT8-010 ENSP00000387678
ENST00000417052
C9K032
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Show » 99 10 No 1
SYT8-011 ENSP00000392469
ENST00000430303
C9J253
Show all »
Show » 102 10.3 No 1