SSRP1

GENE INFORMATION

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Gene name

SSRP1 (HGNC Symbol)

Synonyms

FACT80

Description

Structure specific recognition protein 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q12.1

Chromosome location (bp)

57325985 - 57335877

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000149136 (version 78.38)

Entrez gene

6749

UniProt

Q08945 (UniProt - Evidence at protein level)

neXtProt

NX_Q08945

Antibodypedia

SSRP1 antibodies
 

PROTEIN VIEW

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SSRP1-001
 
SSRP1-003
 
SSRP1-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SSRP1-001 ENSP00000278412
ENST00000278412
Q08945
Show all »
Show » Show » 709 81.1 No 0
SSRP1-003 ENSP00000434546
ENST00000529002
E9PPZ7
Show all »
Show » Show » 154 17.6 No 0
SSRP1-004 ENSP00000431154
ENST00000526696
E9PMD4
Show all »
Show » Show » 192 22.1 No 0