RPS3 - Gene info - The Human Protein Atlas

RPS3

TISSUE

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SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	RPS3 (HGNC Symbol)
Synonyms	FLJ26283, FLJ27450, MGC87870, S3
Description	Ribosomal protein S3 (HGNC Symbol)
Entrez gene summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Chromosome	11
Cytoband	q13.4
Chromosome location (bp)	75399486 - 75422280
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149273 (version 78.38)
Entrez gene	6188
UniProt	P23396 (UniProt - Evidence at protein level)
neXtProt	NX_P23396
Antibodypedia	RPS3 antibodies

PROTEIN VIEW

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RPS3-001		RPS3-004		RPS3-007		RPS3-008		RPS3-013		RPS3-014		RPS3-016		RPS3-019		RPS3-020		RPS3-021		RPS3-022

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
RPS3-001	ENSP00000434643 ENST00000531188	P23396 Show all » « Hide P23396 [Direct mapping] 40S ribosomal protein S3 Q9NQS8 [Target identity:65%; Query identity:100%] Ribosomal protein S3 {ECO:0000313\|EMBL:AAF82383.1} F2Z2S8 [Target identity:48%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000433155} E9PSF4 [Target identity:42%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000416745} E9PJN9 [Target identity:14%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000435566}	Show » « Hide Enzymes ENZYME proteins Lyases Ribosomal proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000737 [DNA catabolic process, endonucleolytic] GO:0002181 [cytoplasmic translation] GO:0003684 [damaged DNA binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0003735 [structural constituent of ribosome] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005840 [ribosome] GO:0005925 [focal adhesion] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006414 [translational elongation] GO:0006415 [translational termination] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0006974 [cellular response to DNA damage stimulus] GO:0010467 [gene expression] GO:0015935 [small ribosomal subunit] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0022627 [cytosolic small ribosomal subunit] GO:0030529 [ribonucleoprotein complex] GO:0032587 [ruffle membrane] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0045738 [negative regulation of DNA repair] GO:0051018 [protein kinase A binding] GO:0051059 [NF-kappaB binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051536 [iron-sulfur cluster binding] GO:0070062 [extracellular vesicular exosome] GO:0071159 [NF-kappaB complex] GO:1902546 [positive regulation of DNA N-glycosylase activity] GO:2001235 [positive regulation of apoptotic signaling pathway]	243	26.7	No	0
RPS3-004	ENSP00000436971 ENST00000527446	P23396 Show all » « Hide P23396 [Direct mapping] 40S ribosomal protein S3 Q9NQS8 [Target identity:65%; Query identity:100%] Ribosomal protein S3 {ECO:0000313\|EMBL:AAF82383.1} F2Z2S8 [Target identity:48%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000433155} E9PSF4 [Target identity:42%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000416745} E9PJN9 [Target identity:14%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000435566}	Show » « Hide Enzymes ENZYME proteins Lyases Ribosomal proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000737 [DNA catabolic process, endonucleolytic] GO:0002181 [cytoplasmic translation] GO:0003684 [damaged DNA binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0003735 [structural constituent of ribosome] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005840 [ribosome] GO:0005925 [focal adhesion] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006414 [translational elongation] GO:0006415 [translational termination] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0006974 [cellular response to DNA damage stimulus] GO:0010467 [gene expression] GO:0015935 [small ribosomal subunit] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0022627 [cytosolic small ribosomal subunit] GO:0030529 [ribonucleoprotein complex] GO:0032587 [ruffle membrane] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0045738 [negative regulation of DNA repair] GO:0051018 [protein kinase A binding] GO:0051059 [NF-kappaB binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051536 [iron-sulfur cluster binding] GO:0070062 [extracellular vesicular exosome] GO:0071159 [NF-kappaB complex] GO:1902546 [positive regulation of DNA N-glycosylase activity] GO:2001235 [positive regulation of apoptotic signaling pathway]	243	26.7	No	0
RPS3-007	ENSP00000433155 ENST00000530164	F2Z2S8 Show all » « Hide F2Z2S8 [Target identity:100%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000433155}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003723 [RNA binding]	117	13.1	No	0
RPS3-008	ENSP00000436556 ENST00000525933	E9PSF4 Show all » « Hide E9PSF4 [Target identity:60%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000416745} E9PJN9 [Target identity:21%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000435566}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation]	171	18.6	No	0
RPS3-013	ENSP00000416745 ENST00000422465	E9PSF4 Show all » « Hide E9PSF4 [Target identity:100%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000416745} E9PJN9 [Target identity:34%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000435566}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation]	103	11.2	No	0
RPS3-014	ENSP00000278572 ENST00000278572	P23396 Show all » « Hide P23396 [Direct mapping] 40S ribosomal protein S3 Q9NQS8 [Target identity:61%; Query identity:100%] Ribosomal protein S3 {ECO:0000313\|EMBL:AAF82383.1} E9PSF4 [Target identity:39%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000416745} E9PJN9 [Target identity:13%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000435566}	Show » « Hide Enzymes ENZYME proteins Lyases Ribosomal proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000737 [DNA catabolic process, endonucleolytic] GO:0002181 [cytoplasmic translation] GO:0003684 [damaged DNA binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0003735 [structural constituent of ribosome] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005840 [ribosome] GO:0005925 [focal adhesion] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006414 [translational elongation] GO:0006415 [translational termination] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0006974 [cellular response to DNA damage stimulus] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0022627 [cytosolic small ribosomal subunit] GO:0030529 [ribonucleoprotein complex] GO:0032587 [ruffle membrane] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0045738 [negative regulation of DNA repair] GO:0051018 [protein kinase A binding] GO:0051059 [NF-kappaB binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051536 [iron-sulfur cluster binding] GO:0070062 [extracellular vesicular exosome] GO:0071159 [NF-kappaB complex] GO:1902546 [positive regulation of DNA N-glycosylase activity] GO:2001235 [positive regulation of apoptotic signaling pathway]	259	28.5	No	0
RPS3-016	ENSP00000436335 ENST00000534440	E9PPU1 Show all » « Hide E9PPU1 [Target identity:100%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000436335}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003723 [RNA binding]	158	17.4	No	0
RPS3-019	ENSP00000435566 ENST00000528847	E9PJN9 Show all » « Hide E9PJN9 [Target identity:100%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000435566}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation]	36	3.8	No	0
RPS3-020	ENSP00000435457 ENST00000527273	E9PK82 Show all » « Hide E9PK82 [Target identity:100%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000435457}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003723 [RNA binding]	128	14.3	No	0
RPS3-021	ENSP00000433421 ENST00000526608	E9PL09 Show all » « Hide E9PL09 [Target identity:100%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000433421} E9PSF4 [Target identity:44%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000416745} E9PJN9 [Target identity:15%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000435566}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015935 [small ribosomal subunit]	231	25.4	No	0
RPS3-022	ENSP00000433821 ENST00000524851	P23396 Show all » « Hide P23396 [Direct mapping] 40S ribosomal protein S3 Q9NQS8 [Target identity:65%; Query identity:100%] Ribosomal protein S3 {ECO:0000313\|EMBL:AAF82383.1} F2Z2S8 [Target identity:48%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000433155} E9PSF4 [Target identity:42%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000416745} E9PJN9 [Target identity:14%; Query identity:100%] 40S ribosomal protein S3 {ECO:0000313\|Ensembl:ENSP00000435566}	Show » « Hide Enzymes ENZYME proteins Lyases Ribosomal proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000737 [DNA catabolic process, endonucleolytic] GO:0002181 [cytoplasmic translation] GO:0003684 [damaged DNA binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0003735 [structural constituent of ribosome] GO:0003906 [DNA-(apurinic or apyrimidinic site) lyase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005840 [ribosome] GO:0005925 [focal adhesion] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006414 [translational elongation] GO:0006415 [translational termination] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0006974 [cellular response to DNA damage stimulus] GO:0010467 [gene expression] GO:0015935 [small ribosomal subunit] GO:0016020 [membrane] GO:0016032 [viral process] GO:0016070 [RNA metabolic process] GO:0016071 [mRNA metabolic process] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0019899 [enzyme binding] GO:0019901 [protein kinase binding] GO:0022627 [cytosolic small ribosomal subunit] GO:0030529 [ribonucleoprotein complex] GO:0032587 [ruffle membrane] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0045738 [negative regulation of DNA repair] GO:0051018 [protein kinase A binding] GO:0051059 [NF-kappaB binding] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0051536 [iron-sulfur cluster binding] GO:0070062 [extracellular vesicular exosome] GO:0071159 [NF-kappaB complex] GO:1902546 [positive regulation of DNA N-glycosylase activity] GO:2001235 [positive regulation of apoptotic signaling pathway]	243	26.7	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.