MTA2 - Gene info - The Human Protein Atlas

MTA2

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TISSUE

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SUBCELL

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CELL LINE

CANCER

GENE INFORMATION

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Gene name	MTA2 (HGNC Symbol)
Synonyms	MTA1-L1, MTA1L1
Description	Metastasis associated 1 family, member 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacetylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis. [provided by RefSeq, May 2011]
Chromosome	11
Cytoband	q12.3
Chromosome location (bp)	62593214 - 62601840
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000149480 (version 78.38)
Entrez gene	9219
UniProt	O94776 (UniProt - Evidence at protein level)
neXtProt	NX_O94776
Antibodypedia	MTA2 antibodies

PROTEIN VIEW

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MTA2-001		MTA2-002		MTA2-003

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
MTA2-001	ENSP00000278823 ENST00000278823	O94776 Show all » « Hide O94776 [Direct mapping] Metastasis-associated protein MTA2 A0A024R534 [Target identity:100%; Query identity:100%] Metastasis associated 1 family, member 2, isoform CRA_a {ECO:0000313\|EMBL:EAW74032.1}	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0000989 [transcription factor binding transcription factor activity] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004407 [histone deacetylase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006306 [DNA methylation] GO:0006333 [chromatin assembly or disassembly] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016575 [histone deacetylation] GO:0016581 [NuRD complex] GO:0031492 [nucleosomal DNA binding] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043234 [protein complex] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]	668	75	No	0
MTA2-002	ENSP00000431346 ENST00000524902	O94776 Show all » « Hide O94776 [Direct mapping] Metastasis-associated protein MTA2	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000118 [histone deacetylase complex] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006333 [chromatin assembly or disassembly] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016581 [NuRD complex] GO:0031492 [nucleosomal DNA binding] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043234 [protein complex] GO:0043565 [sequence-specific DNA binding]	495	55	No	0
MTA2-003	ENSP00000431797 ENST00000527204	O94776 Show all » « Hide O94776 [Direct mapping] Metastasis-associated protein MTA2	Show » « Hide Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000118 [histone deacetylase complex] GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding] GO:0001085 [RNA polymerase II transcription factor binding] GO:0001103 [RNA polymerase II repressing transcription factor binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006333 [chromatin assembly or disassembly] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0016020 [membrane] GO:0016581 [NuRD complex] GO:0031492 [nucleosomal DNA binding] GO:0043044 [ATP-dependent chromatin remodeling] GO:0043234 [protein complex] GO:0043565 [sequence-specific DNA binding]	495	55	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.