MS4A2

GENE INFORMATION

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Gene name

MS4A2 (HGNC Symbol)

Synonyms

APY, FCER1B, IGER, MS4A1

Description

Membrane-spanning 4-domains, subfamily A, member 2 (HGNC Symbol)

Entrez gene summary

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation. [provided by RefSeq, Mar 2012]

Chromosome

11

Cytoband

q12.1

Chromosome location (bp)

60088261 - 60098466

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000149534 (version 78.38)

Entrez gene

2206

UniProt

Q01362 (UniProt - Evidence at transcript level)

neXtProt

NX_Q01362

Antibodypedia

MS4A2 antibodies
 

PROTEIN VIEW

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MS4A2-001
 
MS4A2-003
 
MS4A2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MS4A2-001 ENSP00000278888
ENST00000278888
Q01362
Show all »
Show » Show » 244 26.5 No 4
MS4A2-003 ENSP00000433311
ENST00000524868
E9PLJ1
Show all »
Show » 41 4.5 No 0
MS4A2-201 ENSP00000482594
ENST00000617306
E9PLJ1
Show all »
Show » Show » 199 21.6 No 2