HMGA2

GENE INFORMATION

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Gene name

HMGA2 (HGNC Symbol)

Synonyms

BABL, HMGIC, LIPO

Description

High mobility group AT-hook 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q14.3

Chromosome location (bp)

65824131 - 65966295

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000149948 (version 78.38)

Entrez gene

8091

UniProt

P52926 (UniProt - Evidence at protein level)

neXtProt

NX_P52926

Antibodypedia

HMGA2 antibodies
 

PROTEIN VIEW

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HMGA2-001
 
HMGA2-003
 
HMGA2-005
 
HMGA2-006
 
HMGA2-008
 
HMGA2-011
 
HMGA2-013
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HMGA2-001 ENSP00000384026
ENST00000403681
P52926
Show all »
Show » Show » 109 11.8 No 0
HMGA2-003 ENSP00000437621
ENST00000536545
F5H6H0
Show all »
Show » Show » 147 16.4 No 0
HMGA2-005 ENSP00000377206
ENST00000393578
P52926
Show all »
Show » Show » 90 9.7 No 0
HMGA2-006 ENSP00000407306
ENST00000425208
P52926
Show all »
Show » Show » 92 10.1 No 0
HMGA2-008 ENSP00000346658
ENST00000354636
P52926
Show all »
Show » Show » 106 11.5 No 0
HMGA2-011 ENSP00000439317
ENST00000541363
F5H2U8
Show all »
Show » Show » 99 10.8 No 0
HMGA2-013 ENSP00000377205
ENST00000393577
F5H2A4
Show all »
Show » Show » 118 12.7 No 0