IL18 - Gene info - The Human Protein Atlas

Gene name

IL18 (HGNC Symbol)

Synonyms

IGIF, IL-18, IL-1g, IL1F4

Description

Interleukin 18 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

Chromosome

Cytoband

q23.1

Chromosome location (bp)

112143251 - 112164117

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000150782 (version 78.38)

Entrez gene

3606

UniProt

Q14116 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL18-001

ENSP00000280357
ENST00000280357

Q14116
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Q14116 [Direct mapping]
Interleukin-18
Q9NQ49 [Target identity:23%; Query identity:100%]
Interleukin-18 {ECO:0000313|EMBL:CAC01436.1}

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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000165 [MAPK cascade]
GO:0001525 [angiogenesis]
GO:0005125 [cytokine activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007267 [cell-cell signaling]
GO:0010628 [positive regulation of gene expression]
GO:0030101 [natural killer cell activation]
GO:0030155 [regulation of cell adhesion]
GO:0030431 [sleep]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032819 [positive regulation of natural killer cell proliferation]
GO:0034105 [positive regulation of tissue remodeling]
GO:0042033 [chemokine biosynthetic process]
GO:0042088 [T-helper 1 type immune response]
GO:0042092 [type 2 immune response]
GO:0042094 [interleukin-2 biosynthetic process]
GO:0042095 [interferon-gamma biosynthetic process]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042231 [interleukin-13 biosynthetic process]
GO:0042253 [granulocyte macrophage colony-stimulating factor biosynthetic process]
GO:0042346 [positive regulation of NF-kappaB import into nucleus]
GO:0045662 [negative regulation of myoblast differentiation]
GO:0050729 [positive regulation of inflammatory response]
GO:0051142 [positive regulation of NK T cell proliferation]
GO:0070062 [extracellular vesicular exosome]
GO:0071407 [cellular response to organic cyclic compound]

193

22.3

IL18-003

ENSP00000434561
ENST00000524595

Q14116
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Q14116 [Direct mapping]
Interleukin-18
A0A024R3E0 [Target identity:100%; Query identity:100%]
Interleukin 18 (Interferon-gamma-inducing factor), isoform CRA_a {ECO:0000313|EMBL:EAW67185.1}
Q9NQ49 [Target identity:23%; Query identity:100%]
Interleukin-18 {ECO:0000313|EMBL:CAC01436.1}

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GO:0000165 [MAPK cascade]
GO:0001525 [angiogenesis]
GO:0005125 [cytokine activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007267 [cell-cell signaling]
GO:0030155 [regulation of cell adhesion]
GO:0030431 [sleep]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032819 [positive regulation of natural killer cell proliferation]
GO:0034105 [positive regulation of tissue remodeling]
GO:0042033 [chemokine biosynthetic process]
GO:0042088 [T-helper 1 type immune response]
GO:0042092 [type 2 immune response]
GO:0042094 [interleukin-2 biosynthetic process]
GO:0042095 [interferon-gamma biosynthetic process]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042231 [interleukin-13 biosynthetic process]
GO:0042253 [granulocyte macrophage colony-stimulating factor biosynthetic process]
GO:0050729 [positive regulation of inflammatory response]
GO:0051142 [positive regulation of NK T cell proliferation]
GO:0070062 [extracellular vesicular exosome]
GO:0071407 [cellular response to organic cyclic compound]

189

21.9

IL18-006

ENSP00000434161
ENST00000528832

Q14116
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Q14116 [Direct mapping]
Interleukin-18
Q9NQ49 [Target identity:23%; Query identity:100%]
Interleukin-18 {ECO:0000313|EMBL:CAC01436.1}

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GO:0000165 [MAPK cascade]
GO:0001525 [angiogenesis]
GO:0005125 [cytokine activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007267 [cell-cell signaling]
GO:0030155 [regulation of cell adhesion]
GO:0030431 [sleep]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032725 [positive regulation of granulocyte macrophage colony-stimulating factor production]
GO:0032729 [positive regulation of interferon-gamma production]
GO:0032740 [positive regulation of interleukin-17 production]
GO:0032819 [positive regulation of natural killer cell proliferation]
GO:0034105 [positive regulation of tissue remodeling]
GO:0042033 [chemokine biosynthetic process]
GO:0042088 [T-helper 1 type immune response]
GO:0042092 [type 2 immune response]
GO:0042094 [interleukin-2 biosynthetic process]
GO:0042095 [interferon-gamma biosynthetic process]
GO:0042104 [positive regulation of activated T cell proliferation]
GO:0042231 [interleukin-13 biosynthetic process]
GO:0042253 [granulocyte macrophage colony-stimulating factor biosynthetic process]
GO:0050729 [positive regulation of inflammatory response]
GO:0051142 [positive regulation of NK T cell proliferation]
GO:0070062 [extracellular vesicular exosome]
GO:0071407 [cellular response to organic cyclic compound]

193

22.3

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.