THRB - Gene info - The Human Protein Atlas

THRB

TISSUE

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SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	THRB (HGNC Symbol)
Synonyms	ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2
Description	Thyroid hormone receptor, beta (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	p24.2
Chromosome location (bp)	24117160 - 24495282
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000151090 (version 78.38)
Entrez gene	7068
UniProt	P10828 (UniProt - Evidence at protein level)
neXtProt	NX_P10828
Antibodypedia	THRB antibodies

PROTEIN VIEW

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THRB-001		THRB-002		THRB-003		THRB-004		THRB-005		THRB-006		THRB-008		THRB-009		THRB-010		THRB-011		THRB-012		THRB-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
THRB-001	ENSP00000348827 ENST00000356447	P10828 Show all » « Hide P10828 [Direct mapping] Thyroid hormone receptor beta F1D8N7 [Target identity:100%; Query identity:100%] Thyroid hormone nuclear receptor beta variant 1 {ECO:0000313\|EMBL:ADZ17336.1}; Thyroid hormone receptor, beta (Erythroblastic leukemia viral (V-erb-a) oncogene homolog 2, avian), isoform CRA_a {ECO:0000313\|EMBL:EAW64346.1} C9JNQ4 [Target identity:28%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000414100} J3KR21 [Target identity:26%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000414910} C9JJM3 [Target identity:24%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000395362} C9JTN1 [Target identity:22%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000399573} C9JHC2 [Target identity:14%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000404233} C9JZS5 [Target identity:13%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000393932}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003714 [transcription corepressor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0070062 [extracellular vesicular exosome] GO:0070324 [thyroid hormone binding]	461	52.8	No	0
THRB-002	ENSP00000414910 ENST00000453729	J3KR21 Show all » « Hide J3KR21 [Target identity:100%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000414910} C9JJM3 [Target identity:94%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000395362} C9JTN1 [Target identity:85%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000399573} C9JHC2 [Target identity:55%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000404233} C9JZS5 [Target identity:52%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000393932}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)		121	13.9	No	0
THRB-003	ENSP00000280696 ENST00000280696	P10828 Show all » « Hide P10828 [Direct mapping] Thyroid hormone receptor beta	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003714 [transcription corepressor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0070062 [extracellular vesicular exosome] GO:0070324 [thyroid hormone binding]	476	54.4	No	0
THRB-004	ENSP00000414444 ENST00000416420	P10828 Show all » « Hide P10828 [Direct mapping] Thyroid hormone receptor beta F1D8N7 [Target identity:100%; Query identity:100%] Thyroid hormone nuclear receptor beta variant 1 {ECO:0000313\|EMBL:ADZ17336.1}; Thyroid hormone receptor, beta (Erythroblastic leukemia viral (V-erb-a) oncogene homolog 2, avian), isoform CRA_a {ECO:0000313\|EMBL:EAW64346.1} C9JNQ4 [Target identity:28%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000414100} J3KR21 [Target identity:26%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000414910} C9JJM3 [Target identity:24%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000395362} C9JTN1 [Target identity:22%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000399573} C9JHC2 [Target identity:14%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000404233} C9JZS5 [Target identity:13%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000393932}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003714 [transcription corepressor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0070062 [extracellular vesicular exosome] GO:0070324 [thyroid hormone binding]	461	52.8	No	0
THRB-005	ENSP00000404898 ENST00000415021	P10828 Show all » « Hide P10828 [Direct mapping] Thyroid hormone receptor beta J3KR21 [Target identity:99%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000414910} C9JJM3 [Target identity:93%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000395362} C9JTN1 [Target identity:84%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000399573} C9JHC2 [Target identity:54%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000404233} C9JZS5 [Target identity:51%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000393932}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003714 [transcription corepressor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0070062 [extracellular vesicular exosome] GO:0070324 [thyroid hormone binding]	122	14	No	0
THRB-006	ENSP00000388467 ENST00000447875	P10828 Show all » « Hide P10828 [Direct mapping] Thyroid hormone receptor beta J3KR21 [Target identity:99%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000414910} C9JJM3 [Target identity:93%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000395362} C9JTN1 [Target identity:84%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000399573} C9JHC2 [Target identity:54%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000404233} C9JZS5 [Target identity:51%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000393932}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003714 [transcription corepressor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0030522 [intracellular receptor signaling pathway] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0070062 [extracellular vesicular exosome] GO:0070324 [thyroid hormone binding]	122	14	No	0
THRB-008	ENSP00000395362 ENST00000431815	C9JJM3 Show all » « Hide C9JJM3 [Target identity:100%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000395362} C9JTN1 [Target identity:90%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000399573} C9JHC2 [Target identity:58%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000404233} C9JZS5 [Target identity:55%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000393932}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)		114	13	No	0
THRB-009	ENSP00000404233 ENST00000428492	C9JHC2 Show all » « Hide C9JHC2 [Target identity:100%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000404233} C9JZS5 [Target identity:94%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000393932}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)		67	7.7	No	0
THRB-010	ENSP00000399573 ENST00000447414	C9JTN1 Show all » « Hide C9JTN1 [Target identity:100%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000399573} C9JHC2 [Target identity:65%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000404233} C9JZS5 [Target identity:61%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000393932}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)		103	11.9	No	0
THRB-011	ENSP00000414100 ENST00000413780	C9JNQ4 Show all » « Hide C9JNQ4 [Target identity:100%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000414100}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)	Show » « Hide GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0030522 [intracellular receptor signaling pathway] GO:0043565 [sequence-specific DNA binding]	132	15.2	No	0
THRB-012	ENSP00000393932 ENST00000418247	C9JZS5 Show all » « Hide C9JZS5 [Target identity:100%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000393932}	Show » « Hide Predicted intracellular proteins Protein evidence (Kim et al 2014)		63	7.4	No	0
THRB-201	ENSP00000379904 ENST00000396671	P10828 Show all » « Hide P10828 [Direct mapping] Thyroid hormone receptor beta F1D8N7 [Target identity:100%; Query identity:100%] Thyroid hormone nuclear receptor beta variant 1 {ECO:0000313\|EMBL:ADZ17336.1}; Thyroid hormone receptor, beta (Erythroblastic leukemia viral (V-erb-a) oncogene homolog 2, avian), isoform CRA_a {ECO:0000313\|EMBL:EAW64346.1} C9JNQ4 [Target identity:28%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000414100} J3KR21 [Target identity:26%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000414910} C9JJM3 [Target identity:24%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000395362} C9JTN1 [Target identity:22%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000399573} C9JHC2 [Target identity:14%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000404233} C9JZS5 [Target identity:13%; Query identity:100%] Thyroid hormone receptor beta {ECO:0000313\|Ensembl:ENSP00000393932}	Show » « Hide Nuclear receptors Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0003677 [DNA binding] GO:0003700 [sequence-specific DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003714 [transcription corepressor activity] GO:0004887 [thyroid hormone receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007605 [sensory perception of sound] GO:0007621 [negative regulation of female receptivity] GO:0008016 [regulation of heart contraction] GO:0008050 [female courtship behavior] GO:0008270 [zinc ion binding] GO:0009887 [organ morphogenesis] GO:0010467 [gene expression] GO:0019899 [enzyme binding] GO:0030522 [intracellular receptor signaling pathway] GO:0031490 [chromatin DNA binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0060509 [Type I pneumocyte differentiation] GO:0070062 [extracellular vesicular exosome] GO:0070324 [thyroid hormone binding]	461	52.8	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.