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GENE INFORMATION
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The gene information section lists the gene name (HUGO Gene Nomenclature Committee ( HGNC) name if available), any approved gene synonyms, Ensembl gene description, and the Entrez gene summary from the National Center for Biotechnology Information.
The chromosomal and cytoband location of the gene according to Ensembl is reported together with the Ensembl gene identifier and Ensembl database version.
The Entrez gene identifier for the gene is also given. If any of the protein products of
the gene is linked to a UniProt KB/SWISS-PROT entry, links to the UniProt and the
neXtProt databases for these proteins are displayed.
There is also a link to the Antibodypedia portal where validation data for antibodies produced by other suppliers
against this gene can be found.
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Gene name |
SLC30A6 (HGNC Symbol) |
Synonyms |
FLJ31101, ZNT6 |
Description |
Solute carrier family 30 (zinc transporter), member 6 (HGNC Symbol) |
Entrez gene summary |
Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A6, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008] |
Chromosome |
2 |
Cytoband |
p22.3 |
Chromosome location (bp) |
32165841 - 32224379 |
Protein evidence |
Evidence at protein level (all genes) |
Ensembl |
ENSG00000152683 (version 78.38) |
Entrez gene |
55676 |
UniProt |
Q6NXT4 (UniProt - Evidence at protein level) |
neXtProt |
NX_Q6NXT4 |
Antibodypedia |
SLC30A6 antibodies |
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PROTEIN VIEW
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The protein view displays protein features. The tabs at the top of the protein view section can be used to switch between the different splice variants encoded by this gene. The mouse over function displays additional data for the features in the protein view.
At the top of the protein view, the maximum percent sequence identity of the protein to all other proteins from other human genes is shown, using a sliding window of 10 aa residues
(HsID 10) or 50 aa residues (HsID 50) ( read more).
If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS,
SignalP 4.0, and
Phobius
(turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.
Low complexity regions are shown in yellow and InterPro regions in green.
Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed
( read more), and at the bottom of the protein view is the protein scale.
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PROTEIN INFORMATION
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The protein information section displays the alternative protein-coding transcripts (splice variants) encoded by this gene, according to the Ensembl database.
The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant.
The data in the UniProt column can be expanded to show links to all matching
UniProt identifiers for this protein.
The protein classes to which this protein has been assigned are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors
SPOCTOPUS,
SignalP 4.0, and
Phobius) and the number of predicted transmembrane region(s) (according to
MDM) are also reported.
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Splice variant |
Ensembl |
UniProt |
Protein class |
Gene ontology |
Length (aa) |
Molecular mass (kDa) |
Signal peptide (predicted) |
Transmembrane regions (predicted)
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SLC30A6-001 |
ENSP00000282587
ENST00000282587
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Q6NXT4 Show all »
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Q6NXT4 [Direct mapping]Zinc transporter 6 B5MCR8 [Target identity:83%; Query identity:100%]Solute carrier family 30 (Zinc transporter), member 6, isoform CRA_b {ECO:0000313|EMBL:EAX00457.1}; Zinc transporter 6 {ECO:0000313|Ensembl:ENSP00000384041} B3KU87 [Target identity:57%; Query identity:100%]Solute carrier family 30 (Zinc transporter), member 6, isoform CRA_c {ECO:0000313|EMBL:EAX00458.1}; Zinc transporter 6 {ECO:0000313|Ensembl:ENSP00000349563}; cDNA FLJ39353 fis, clone PEBLM2002432, highly similar to Homo sapiens solute carrier family 30 (zinc transporter), member 6 (SLC30A6), mRNA {ECO:0000313|EMBL:BAG53349.1}; cDNA FLJ45816 fis, clone NT2RP7019682, highly similar to Homo sapiens solute carrier family 30 (zinc transporter), member 6 (SLC30A6), mRNA {ECO:0000313|EMBL:BAG54557.1}
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Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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461 |
51.1 |
No |
6 |
SLC30A6-002 |
ENSP00000368648
ENST00000379343
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Q6NXT4 Show all »
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Q6NXT4 [Direct mapping]Zinc transporter 6 B5MCR8 [Target identity:77%; Query identity:100%]Solute carrier family 30 (Zinc transporter), member 6, isoform CRA_b {ECO:0000313|EMBL:EAX00457.1}; Zinc transporter 6 {ECO:0000313|Ensembl:ENSP00000384041} B3KU87 [Target identity:52%; Query identity:100%]Solute carrier family 30 (Zinc transporter), member 6, isoform CRA_c {ECO:0000313|EMBL:EAX00458.1}; Zinc transporter 6 {ECO:0000313|Ensembl:ENSP00000349563}; cDNA FLJ39353 fis, clone PEBLM2002432, highly similar to Homo sapiens solute carrier family 30 (zinc transporter), member 6 (SLC30A6), mRNA {ECO:0000313|EMBL:BAG53349.1}; cDNA FLJ45816 fis, clone NT2RP7019682, highly similar to Homo sapiens solute carrier family 30 (zinc transporter), member 6 (SLC30A6), mRNA {ECO:0000313|EMBL:BAG54557.1}
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Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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501 |
55.8 |
No |
6 |
SLC30A6-005 |
ENSP00000384041
ENST00000406369
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B5MCR8 Show all »
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B5MCR8 [Target identity:100%; Query identity:100%]Solute carrier family 30 (Zinc transporter), member 6, isoform CRA_b {ECO:0000313|EMBL:EAX00457.1}; Zinc transporter 6 {ECO:0000313|Ensembl:ENSP00000384041} B3KU87 [Target identity:68%; Query identity:100%]Solute carrier family 30 (Zinc transporter), member 6, isoform CRA_c {ECO:0000313|EMBL:EAX00458.1}; Zinc transporter 6 {ECO:0000313|Ensembl:ENSP00000349563}; cDNA FLJ39353 fis, clone PEBLM2002432, highly similar to Homo sapiens solute carrier family 30 (zinc transporter), member 6 (SLC30A6), mRNA {ECO:0000313|EMBL:BAG53349.1}; cDNA FLJ45816 fis, clone NT2RP7019682, highly similar to Homo sapiens solute carrier family 30 (zinc transporter), member 6 (SLC30A6), mRNA {ECO:0000313|EMBL:BAG54557.1}
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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387 |
42.5 |
No |
4 |
SLC30A6-006 |
ENSP00000393946
ENST00000440718
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C9JZR9 Show all »
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C9JZR9 [Target identity:99%; Query identity:100%]Zinc transporter 6 {ECO:0000313|Ensembl:ENSP00000393946}
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Show »
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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179 |
20 |
No |
4 |
SLC30A6-201 |
ENSP00000349563
ENST00000357055
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Q6NXT4 Show all »
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Q6NXT4 [Direct mapping]Zinc transporter 6 B5MCR8 [Target identity:89%; Query identity:100%]Solute carrier family 30 (Zinc transporter), member 6, isoform CRA_b {ECO:0000313|EMBL:EAX00457.1}; Zinc transporter 6 {ECO:0000313|Ensembl:ENSP00000384041} B3KU87 [Target identity:61%; Query identity:100%]Solute carrier family 30 (Zinc transporter), member 6, isoform CRA_c {ECO:0000313|EMBL:EAX00458.1}; Zinc transporter 6 {ECO:0000313|Ensembl:ENSP00000349563}; cDNA FLJ39353 fis, clone PEBLM2002432, highly similar to Homo sapiens solute carrier family 30 (zinc transporter), member 6 (SLC30A6), mRNA {ECO:0000313|EMBL:BAG53349.1}; cDNA FLJ45816 fis, clone NT2RP7019682, highly similar to Homo sapiens solute carrier family 30 (zinc transporter), member 6 (SLC30A6), mRNA {ECO:0000313|EMBL:BAG54557.1} C9JZR9 [Target identity:41%; Query identity:100%]Zinc transporter 6 {ECO:0000313|Ensembl:ENSP00000393946}
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Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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432 |
47.6 |
No |
6 |
SLC30A6-202 |
ENSP00000399005
ENST00000435660
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Q6NXT4 Show all »
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Q6NXT4 [Direct mapping]Zinc transporter 6
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Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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438 |
48.6 |
No |
6 |
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