CD8A

GENE INFORMATION

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Gene name

CD8A (HGNC Symbol)

Synonyms

CD8

Description

CD8a molecule (HGNC Symbol)

Entrez gene summary

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Chromosome

2

Cytoband

p11.2

Chromosome location (bp)

86784610 - 86808396

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000153563 (version 78.38)

Entrez gene

925

UniProt

P01732 (UniProt - Evidence at protein level)

neXtProt

NX_P01732

Antibodypedia

CD8A antibodies
 

PROTEIN VIEW

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CD8A-001
 
CD8A-002
 
CD8A-004
 
CD8A-006
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CD8A-001 ENSP00000283635
ENST00000283635
P01732
Show all »
Show » Show » 235 25.7 Yes 1
CD8A-002 ENSP00000321631
ENST00000352580
P01732
Show all »
Show » Show » 198 21.6 Yes 0
CD8A-004 ENSP00000387314
ENST00000409781
B8ZZZ4
Show all »
Show » Show » 198 22.1 Yes 1
CD8A-006 ENSP00000386559
ENST00000409511
P01732
Show all »
Show » Show » 235 25.7 Yes 1