CACNA2D1

GENE INFORMATION

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Gene name

CACNA2D1 (HGNC Symbol)

Synonyms

CACNA2, CACNL2A, LINC01112, lncRNA-N3, MHS3

Description

Calcium channel, voltage-dependent, alpha 2/delta subunit 1 (HGNC Symbol)

Entrez gene summary

The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014]

Chromosome

7

Cytoband

q21.11

Chromosome location (bp)

81946444 - 82443798

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000153956 (version 78.38)

Entrez gene

781

UniProt

P54289 (UniProt - Evidence at protein level)

neXtProt

NX_P54289

Antibodypedia

CACNA2D1 antibodies
 

PROTEIN VIEW

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CACNA2D1-001
 
CACNA2D1-002
 
CACNA2D1-005
 
CACNA2D1-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CACNA2D1-001 ENSP00000349320
ENST00000356860
P54289
Show all »
Show » Show » 1091 123.2 Yes 1
CACNA2D1-002 ENSP00000405395
ENST00000423588
E7ERK3
Show all »
Show » 309 34.6 Yes 0
CACNA2D1-005 ENSP00000409374
ENST00000443883
Show » 280 32.4 No 0
CACNA2D1-201 ENSP00000348589
ENST00000356253
P54289
Show all »
Show » Show » 1103 124.6 Yes 1