NRGN

GENE INFORMATION

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Gene name

NRGN (HGNC Symbol)

Synonyms

RC3

Description

Neurogranin (protein kinase C substrate, RC3) (HGNC Symbol)

Entrez gene summary

Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

q24.2

Chromosome location (bp)

124739846 - 124747210

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000154146 (version 78.38)

Entrez gene

4900

UniProt

Q92686 (UniProt - Evidence at protein level)

neXtProt

NX_Q92686

Antibodypedia

NRGN antibodies
 

PROTEIN VIEW

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NRGN-001
 
NRGN-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NRGN-001 ENSP00000284292
ENST00000284292
Q92686
Show all »
Show » Show » 78 7.6 No 0
NRGN-002 ENSP00000399591
ENST00000412681
Q92686
Show all »
Show » Show » 78 7.6 No 0