CDH12

GENE INFORMATION

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Gene name

CDH12 (HGNC Symbol)

Synonyms

Br-cadherin, CDHB

Description

Cadherin 12, type 2 (N-cadherin 2) (HGNC Symbol)

Entrez gene summary

This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

p14.3

Chromosome location (bp)

21750673 - 22853622

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000154162 (version 78.38)

Entrez gene

1010

UniProt

P55289 (UniProt - Evidence at transcript level)

neXtProt

NX_P55289

Antibodypedia

CDH12 antibodies
 

PROTEIN VIEW

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CDH12-001
 
CDH12-002
 
CDH12-003
 
CDH12-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDH12-001 ENSP00000371689
ENST00000382254
P55289
Show all »
Show » Show » 794 88.3 Yes 1
CDH12-002 ENSP00000423577
ENST00000504376
P55289
Show all »
Show » Show » 794 88.3 Yes 1
CDH12-003 ENSP00000428786
ENST00000522262
P55289
Show all »
Show » Show » 754 84 Yes 1
CDH12-201 ENSP00000480493
ENST00000619694
P55289
Show all »
Show » Show » 794 88.3 Yes 1