XPC

GENE INFORMATION

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Gene name

XPC (HGNC Symbol)

Synonyms

RAD4, XPCC

Description

Xeroderma pigmentosum, complementation group C (HGNC Symbol)

Entrez gene summary

This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

Chromosome

3

Cytoband

p25.1

Chromosome location (bp)

14145147 - 14178783

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000154767 (version 78.38)

Entrez gene

7508

UniProt

Q01831 (UniProt - Evidence at protein level)

neXtProt

NX_Q01831

Antibodypedia

XPC antibodies
 

PROTEIN VIEW

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XPC-001
 
XPC-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

XPC-001 ENSP00000285021
ENST00000285021
Q01831
Show all »
Show » Show » 940 106 No 0
XPC-007 ENSP00000423867
ENST00000511155
E7EUB5
Show all »
Show » Show » 168 18.6 No 0