PPP2R2B

GENE INFORMATION

? »

Gene name

PPP2R2B (HGNC Symbol)

Synonyms

PR52B, PR55-BETA, SCA12

Description

Protein phosphatase 2, regulatory subunit B, beta (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q32

Chromosome location (bp)

146581146 - 147084784

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000156475 (version 78.38)

Entrez gene

5521

UniProt

Q00005 (UniProt - Evidence at protein level)

neXtProt

NX_Q00005

Antibodypedia

PPP2R2B antibodies
 

PROTEIN VIEW

? »
 
 
 
PPP2R2B-001
 
PPP2R2B-002
 
PPP2R2B-003
 
PPP2R2B-008
 
PPP2R2B-009
 
PPP2R2B-011
 
PPP2R2B-013
 
PPP2R2B-017
 
PPP2R2B-201
 
PPP2R2B-202
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PPP2R2B-001 ENSP00000377936
ENST00000394414
Q00005
Show all »
Show » Show » 509 58.9 No 0
PPP2R2B-002 ENSP00000377931
ENST00000394409
Q00005
Show all »
Show » Show » 443 51.7 No 0
PPP2R2B-003 ENSP00000336591
ENST00000336640
Q00005
Show all »
Show » Show » 446 52 No 0
PPP2R2B-008 ENSP00000431320
ENST00000508545
Q00005
Show all »
Show » Show » 432 50.4 No 0
PPP2R2B-009 ENSP00000421396
ENST00000504198
Q00005
Show all »
Show » Show » 449 52.1 No 0
PPP2R2B-011 ENSP00000421224
ENST00000508267
D6RGF9
Show all »
Show » Show » 58 6.7 No 0
PPP2R2B-013 ENSP00000425828
ENST00000512984
Show » 78 9.2 No 0
PPP2R2B-017 ENSP00000377933
ENST00000394411
Q00005
Show all »
Show » Show » 443 51.7 No 0
PPP2R2B-201 ENSP00000377935
ENST00000394413
Q00005
Show all »
Show » Show » 432 50.4 No 0
PPP2R2B-202 ENSP00000398779
ENST00000453001
Q00005
Show all »
Show » Show » 432 50.4 No 0