ATP2B2 - Gene info - The Human Protein Atlas

Gene name

ATP2B2 (HGNC Symbol)

Synonyms

PMCA2

Description

ATPase, Ca++ transporting, plasma membrane 2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Chromosome

Cytoband

p25.3

Chromosome location (bp)

10324023 - 10708031

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000157087 (version 78.38)

Entrez gene

491

UniProt

Q01814 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP2B2-001

ENSP00000324172
ENST00000352432

Q01814
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Q01814 [Direct mapping]
Plasma membrane calcium-transporting ATPase 2
A0A024R2K6 [Target identity:100%; Query identity:100%]
Calcium-transporting ATPase {ECO:0000256|RuleBase:RU361146}
Q4J699 [Target identity:31%; Query identity:100%]
Plasma membrane Ca(2+)-ATPase isoform 2 {ECO:0000313|EMBL:AAA08378.1}
Q4J696 [Target identity:5%; Query identity:100%]
PMCA2 {ECO:0000313|EMBL:AAZ04475.1}

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Enzymes
   ENZYME proteins
   Hydrolases
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0007596 [blood coagulation]
GO:0007605 [sensory perception of sound]
GO:0008022 [protein C-terminus binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030165 [PDZ domain binding]
GO:0030182 [neuron differentiation]
GO:0034220 [ion transmembrane transport]
GO:0046872 [metal ion binding]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]

1243

136.9

ATP2B2-002

ENSP00000373311
ENST00000383800

Q01814
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Q01814 [Direct mapping]
Plasma membrane calcium-transporting ATPase 2
A0A024R2E4 [Target identity:100%; Query identity:100%]
Calcium-transporting ATPase {ECO:0000256|RuleBase:RU361146}
Q4LE63 [Target identity:100%; Query identity:99%]
ATP2B2 variant protein {ECO:0000313|EMBL:BAE06090.1}

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1198

132.6

ATP2B2-003

ENSP00000414854
ENST00000452124

H0Y7S3
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H0Y7S3 [Target identity:100%; Query identity:100%]
Plasma membrane calcium-transporting ATPase 2 {ECO:0000313|Ensembl:ENSP00000414854}

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000166 [nucleotide binding]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0046872 [metal ion binding]
GO:0070588 [calcium ion transmembrane transport]

1099

121.3

ATP2B2-005

ENSP00000380267
ENST00000397077

Q01814
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1198

132.6

ATP2B2-201

ENSP00000353414
ENST00000360273

Q01814
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GO:0000166 [nucleotide binding]
GO:0000902 [cell morphogenesis]
GO:0005388 [calcium-transporting ATPase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005886 [plasma membrane]
GO:0005929 [cilium]
GO:0006200 [ATP catabolic process]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006996 [organelle organization]
GO:0007595 [lactation]
GO:0007596 [blood coagulation]
GO:0007605 [sensory perception of sound]
GO:0007626 [locomotory behavior]
GO:0008022 [protein C-terminus binding]
GO:0008361 [regulation of cell size]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0021549 [cerebellum development]
GO:0021692 [cerebellar Purkinje cell layer morphogenesis]
GO:0021702 [cerebellar Purkinje cell differentiation]
GO:0021707 [cerebellar granule cell differentiation]
GO:0030165 [PDZ domain binding]
GO:0030182 [neuron differentiation]
GO:0030899 [calcium-dependent ATPase activity]
GO:0034220 [ion transmembrane transport]
GO:0040011 [locomotion]
GO:0042428 [serotonin metabolic process]
GO:0042472 [inner ear morphogenesis]
GO:0043025 [neuronal cell body]
GO:0045299 [otolith mineralization]
GO:0046068 [cGMP metabolic process]
GO:0046872 [metal ion binding]
GO:0048167 [regulation of synaptic plasticity]
GO:0048839 [inner ear development]
GO:0050808 [synapse organization]
GO:0050885 [neuromuscular process controlling balance]
GO:0050910 [detection of mechanical stimulus involved in sensory perception of sound]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0051928 [positive regulation of calcium ion transport]
GO:0055085 [transmembrane transport]
GO:0060088 [auditory receptor cell stereocilium organization]
GO:0060113 [inner ear receptor cell differentiation]
GO:0070588 [calcium ion transmembrane transport]
GO:0090102 [cochlea development]

1243

136.9

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.