LRP8 - Gene info - The Human Protein Atlas

Gene name

LRP8 (HGNC Symbol)

Synonyms

APOER2, HSZ75190, LRP-8, MCI1

Description

Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the low density lipoprotein receptor (LDLR) family. Low density lipoprotein receptors are cell surface proteins that play roles in both signal transduction and receptor-mediated endocytosis of specific ligands for lysosomal degradation. The encoded protein plays a critical role in the migration of neurons during development by mediating Reelin signaling, and also functions as a receptor for the cholesterol transport protein apolipoprotein E. Expression of this gene may be a marker for major depressive disorder. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]

Chromosome

Cytoband

p32.3

Chromosome location (bp)

53245539 - 53328070

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000157193 (version 78.38)

Entrez gene

7804

UniProt

Q14114 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

LRP8-001

ENSP00000303634
ENST00000306052

Q14114
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Q14114 [Direct mapping]
Low-density lipoprotein receptor-related protein 8

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001523 [retinoid metabolic process]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005875 [microtubule associated complex]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006508 [proteolysis]
GO:0006629 [lipid metabolic process]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0008035 [high-density lipoprotein particle binding]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019894 [kinesin binding]
GO:0021541 [ammon gyrus development]
GO:0021766 [hippocampus development]
GO:0021819 [layer formation in cerebral cortex]
GO:0021987 [cerebral cortex development]
GO:0030229 [very-low-density lipoprotein particle receptor activity]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0034185 [apolipoprotein binding]
GO:0038025 [reelin receptor activity]
GO:0038026 [reelin-mediated signaling pathway]
GO:0042493 [response to drug]
GO:0043025 [neuronal cell body]
GO:0043235 [receptor complex]
GO:0045860 [positive regulation of protein kinase activity]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050804 [regulation of synaptic transmission]
GO:0061003 [positive regulation of dendritic spine morphogenesis]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:0071363 [cellular response to growth factor stimulus]
GO:0071397 [cellular response to cholesterol]
GO:1900006 [positive regulation of dendrite development]

963

105.6

Yes

LRP8-002

ENSP00000360509
ENST00000371454

Q14114
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Q14114 [Direct mapping]
Low-density lipoprotein receptor-related protein 8
E9PP15 [Target identity:50%; Query identity:100%]
Low-density lipoprotein receptor-related protein 8 {ECO:0000313|Ensembl:ENSP00000437009}

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001523 [retinoid metabolic process]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006508 [proteolysis]
GO:0006629 [lipid metabolic process]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0021541 [ammon gyrus development]
GO:0030229 [very-low-density lipoprotein particle receptor activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0034185 [apolipoprotein binding]
GO:0038025 [reelin receptor activity]
GO:0038026 [reelin-mediated signaling pathway]
GO:0043235 [receptor complex]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050804 [regulation of synaptic transmission]
GO:0061003 [positive regulation of dendritic spine morphogenesis]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:1900006 [positive regulation of dendrite development]

904

99.1

Yes

LRP8-003

ENSP00000346391
ENST00000354412

Q14114
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Q14114 [Direct mapping]
Low-density lipoprotein receptor-related protein 8

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001523 [retinoid metabolic process]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006508 [proteolysis]
GO:0006629 [lipid metabolic process]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0021541 [ammon gyrus development]
GO:0030229 [very-low-density lipoprotein particle receptor activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0034185 [apolipoprotein binding]
GO:0038025 [reelin receptor activity]
GO:0038026 [reelin-mediated signaling pathway]
GO:0043235 [receptor complex]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050804 [regulation of synaptic transmission]
GO:0061003 [positive regulation of dendritic spine morphogenesis]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:1900006 [positive regulation of dendrite development]

700

77.8

Yes

LRP8-004

ENSP00000437009
ENST00000465675

E9PP15
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E9PP15 [Target identity:100%; Query identity:100%]
Low-density lipoprotein receptor-related protein 8 {ECO:0000313|Ensembl:ENSP00000437009}

Show » « Hide

Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0016021 [integral component of membrane]

457

50.9

LRP8-009

ENSP00000436651
ENST00000475501

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]

241

LRP8-011

ENSP00000334522
ENST00000347547

Q14114
Show all » « Hide

Q14114 [Direct mapping]
Low-density lipoprotein receptor-related protein 8

Show » « Hide

GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001523 [retinoid metabolic process]
GO:0004888 [transmembrane signaling receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0006508 [proteolysis]
GO:0006629 [lipid metabolic process]
GO:0006897 [endocytosis]
GO:0006898 [receptor-mediated endocytosis]
GO:0007165 [signal transduction]
GO:0007596 [blood coagulation]
GO:0007603 [phototransduction, visible light]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0021541 [ammon gyrus development]
GO:0030229 [very-low-density lipoprotein particle receptor activity]
GO:0032793 [positive regulation of CREB transcription factor activity]
GO:0034185 [apolipoprotein binding]
GO:0038025 [reelin receptor activity]
GO:0038026 [reelin-mediated signaling pathway]
GO:0043235 [receptor complex]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050804 [regulation of synaptic transmission]
GO:0061003 [positive regulation of dendritic spine morphogenesis]
GO:0061098 [positive regulation of protein tyrosine kinase activity]
GO:1900006 [positive regulation of dendrite development]

793

Yes

LRP8-201

ENSP00000480025
ENST00000613948

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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]

699

77.6

Yes

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.