MMP14

GENE INFORMATION

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Gene name

MMP14 (HGNC Symbol)

Synonyms

MT1-MMP

Description

Matrix metallopeptidase 14 (membrane-inserted) (HGNC Symbol)

Entrez gene summary

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q11.2

Chromosome location (bp)

22836557 - 22849027

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000157227 (version 78.38)

Entrez gene

4323

UniProt

P50281 (UniProt - Evidence at protein level)

neXtProt

NX_P50281

Antibodypedia

MMP14 antibodies
 

PROTEIN VIEW

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MMP14-001
 
MMP14-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MMP14-001 ENSP00000308208
ENST00000311852
P50281
Show all »
Show » Show » 582 65.9 Yes 1
MMP14-007 ENSP00000446989
ENST00000548761
F8W1B7
Show all »
Show » Show » 194 22.3 Yes 0