APPL1

GENE INFORMATION

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Gene name

APPL1 (HGNC Symbol)

Synonyms

APPL

Description

Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

p14.3

Chromosome location (bp)

57227737 - 57273468

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000157500 (version 78.38)

Entrez gene

26060

UniProt

Q9UKG1 (UniProt - Evidence at protein level)

neXtProt

NX_Q9UKG1

Antibodypedia

APPL1 antibodies
 

PROTEIN VIEW

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APPL1-001
 
APPL1-002
 
APPL1-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

APPL1-001 ENSP00000288266
ENST00000288266
Q9UKG1
Show all »
Show » Show » 709 79.7 No 0
APPL1-002 ENSP00000406095
ENST00000444459
C9JAB0
Show all »
Show » 134 15.3 No 0
APPL1-008 ENSP00000419644
ENST00000495803
C9K0C4
Show all »
Show » 114 13 No 0