ERG

GENE INFORMATION

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Gene name

ERG (HGNC Symbol)

Synonyms

erg-3, p55

Description

V-ets avian erythroblastosis virus E26 oncogene homolog (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]

Chromosome

21

Cytoband

q22.2

Chromosome location (bp)

38380027 - 38661780

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000157554 (version 78.38)

Entrez gene

2078

UniProt

P11308 (UniProt - Evidence at protein level)

neXtProt

NX_P11308

Antibodypedia

ERG antibodies
 

PROTEIN VIEW

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 « 
 
ERG-001
 
ERG-002
 
ERG-004
 
ERG-005
 
ERG-007
 
ERG-008
 
ERG-009
 
ERG-013
 
ERG-014
 
ERG-201
 
ERG-202
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ERG-001 ENSP00000288319
ENST00000288319
P11308
Show all »
Show » Show » 479 53.8 No 0
ERG-002 ENSP00000414150
ENST00000417133
P11308
Show all »
Show » Show » 486 54.6 No 0
ERG-004 ENSP00000381871
ENST00000398897
P11308
Show all »
Show » Show » 363 41.4 No 0
ERG-005 ENSP00000381877
ENST00000398905
B5MDW0
Show all »
Show » Show » 455 51.3 No 0
ERG-007 ENSP00000381882
ENST00000398911
P11308
Show all »
Show » Show » 462 52 No 0
ERG-008 ENSP00000381881
ENST00000398910
A8MZ24
Show all »
Show » Show » 463 52 No 0
ERG-009 ENSP00000381879
ENST00000398907
A8MX39
Show all »
Show » Show » 456 51.2 No 0
ERG-013 ENSP00000381891
ENST00000398919
P11308
Show all »
Show » Show » 486 54.6 No 0
ERG-014 ENSP00000396268
ENST00000453032
P11308
Show all »
Show » Show » 387 44 No 0
ERG-201 ENSP00000415659
ENST00000429727
Show » Show » 220 24.8 No 0
ERG-202 ENSP00000394694
ENST00000442448
P11308
Show all »
Show » Show » 462 52 No 0