HPD

GENE INFORMATION

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Gene name

HPD (HGNC Symbol)

Synonyms

4-HPPD, 4HPPD, GLOD3, PPD

Description

4-hydroxyphenylpyruvate dioxygenase (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Chromosome

12

Cytoband

q24.31

Chromosome location (bp)

121839527 - 121863596

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000158104 (version 78.38)

Entrez gene

3242

UniProt

P32754 (UniProt - Evidence at protein level)

neXtProt

NX_P32754

Antibodypedia

HPD antibodies
 

PROTEIN VIEW

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HPD-001
 
HPD-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HPD-001 ENSP00000441677
ENST00000543163
P32754
Show all »
Show » Show » 354 40.5 No 0
HPD-002 ENSP00000289004
ENST00000289004
Show » Show » 393 45 No 0