NRG2

GENE INFORMATION

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Gene name

NRG2 (HGNC Symbol)

Synonyms

Don-1, HRG2, NTAK

Description

Neuregulin 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. Alternative transcript variants encoding distinct isoforms have been described. [provided by RefSeq, May 2010]

Chromosome

5

Cytoband

q31.2

Chromosome location (bp)

139846779 - 140043299

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000158458 (version 78.38)

Entrez gene

9542

UniProt

O14511 (UniProt - Evidence at protein level)

neXtProt

NX_O14511

Antibodypedia

NRG2 antibodies
 

PROTEIN VIEW

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NRG2-001
 
NRG2-002
 
NRG2-006
 
NRG2-007
 
NRG2-012
 
NRG2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

NRG2-001 ENSP00000354910
ENST00000361474
O14511
Show all »
Show » Show » 850 91.7 No 1
NRG2-002 ENSP00000289409
ENST00000289409
O14511
Show all »
Show » Show » 844 90.9 No 1
NRG2-006 ENSP00000342660
ENST00000340391
O14511
Show all »
Show » Show » 647 70.6 No 1
NRG2-007 ENSP00000351323
ENST00000358522
O14511
Show all »
Show » Show » 852 91.8 No 1
NRG2-012 ENSP00000289422
ENST00000289422
O14511
Show all »
Show » Show » 858 92.6 No 1
NRG2-201 ENSP00000444235
ENST00000541337
F5GZS7
Show all »
Show » Show » 784 84.3 No 1