PFKFB1

GENE INFORMATION

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Gene name

PFKFB1 (HGNC Symbol)

Synonyms

PFRX

Description

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the family of bifunctional 6-phosphofructo-2-kinase:fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of this enzyme is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]

Chromosome

X

Cytoband

p11.21

Chromosome location (bp)

54932961 - 54998534

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000158571 (version 78.38)

Entrez gene

5207

UniProt

P16118 (UniProt - Evidence at protein level)

neXtProt

NX_P16118

Antibodypedia

PFKFB1 antibodies
 

PROTEIN VIEW

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PFKFB1-001
 
PFKFB1-201
 
PFKFB1-202
 
PFKFB1-203
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PFKFB1-001 ENSP00000364145
ENST00000375006
P16118
Show all »
Show » Show » 471 54.7 No 0
PFKFB1-201 ENSP00000364131
ENST00000374992
Q4VBA9
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Show » Show » 271 31.4 No 0
PFKFB1-202 ENSP00000444074
ENST00000545676
P16118
Show all »
Show » Show » 406 47.4 No 0
PFKFB1-203 ENSP00000480232
ENST00000614686
I1Z9G3
Show all »
Show » Show » 244 28.3 No 0