STC1

GENE INFORMATION

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Gene name

STC1 (HGNC Symbol)

Synonyms

STC

Description

Stanniocalcin 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

p21.2

Chromosome location (bp)

23841915 - 23854807

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000159167 (version 78.38)

Entrez gene

6781

UniProt

P52823 (UniProt - Evidence at protein level)

neXtProt

NX_P52823

Antibodypedia

STC1 antibodies
 

PROTEIN VIEW

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STC1-001
 
STC1-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

STC1-001 ENSP00000290271
ENST00000290271
P52823
Show all »
Show » Show » 247 27.6 Yes 0
STC1-002 ENSP00000427932
ENST00000524323
B4DN22
Show all »
Show » Show » 178 20.5 No 0