MCM3AP

GENE INFORMATION

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Gene name

MCM3AP (HGNC Symbol)

Synonyms

GANP, KIAA0572, Map80, SAC3

Description

Minichromosome maintenance complex component 3 associated protein (HGNC Symbol)

Entrez gene summary

The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014]

Chromosome

21

Cytoband

q22.3

Chromosome location (bp)

46235126 - 46286297

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160294 (version 78.38)

Entrez gene

8888

UniProt

O60318 (UniProt - Evidence at protein level)

neXtProt

NX_O60318

Antibodypedia

MCM3AP antibodies
 

PROTEIN VIEW

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MCM3AP-001
 
MCM3AP-007
 
MCM3AP-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

MCM3AP-001 ENSP00000380820
ENST00000397708
O60318
Show all »
Show » Show » 1980 218.4 No 0
MCM3AP-007 ENSP00000408934
ENST00000426537
N0GVG8
Show all »
Show » 94 9.6 No 0
MCM3AP-201 ENSP00000291688
ENST00000291688
O60318
Show all »
Show » Show » 1980 218.4 No 0