PCNT

GENE INFORMATION

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Gene name

PCNT (HGNC Symbol)

Synonyms

KEN, KIAA0402, PCN, PCNT2, PCNTB, SCKL4

Description

Pericentrin (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. [provided by RefSeq, Jul 2008]

Chromosome

21

Cytoband

q22.3

Chromosome location (bp)

46324122 - 46445769

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160299 (version 78.38)

Entrez gene

5116

UniProt

O95613 (UniProt - Evidence at protein level)

neXtProt

NX_O95613

Antibodypedia

PCNT antibodies
 

PROTEIN VIEW

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PCNT-001
 
PCNT-007
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PCNT-001 ENSP00000352572
ENST00000359568
O95613
Show all »
Show » Show » 3336 378 No 0
PCNT-007 ENSP00000404708
ENST00000418394
Show » 228 25.8 No 0