SHC1 - Gene info - The Human Protein Atlas

Gene name

SHC1 (HGNC Symbol)

Synonyms

p66, SHC

Description

SHC (Src homology 2 domain containing) transforming protein 1 (HGNC Symbol)

Entrez gene summary

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Chromosome

Cytoband

q21.3

Chromosome location (bp)

154962298 - 154974395

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160691 (version 78.38)

Entrez gene

6464

UniProt

P29353 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SHC1-001

ENSP00000357430
ENST00000368445

P29353
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P29353 [Direct mapping]
SHC-transforming protein 1
X6R6D0 [Target identity:60%; Query identity:100%]
SHC-transforming protein 1 {ECO:0000313|Ensembl:ENSP00000357434}
Q8NFT1 [Target identity:28%; Query identity:100%]
Src homology 2 domain-containing transforming protein 1 isoform p66 {ECO:0000313|EMBL:AAM61859.1}
Q5T181 [Target identity:23%; Query identity:100%]
SHC-transforming protein 1 {ECO:0000313|Ensembl:ENSP00000396162}
Q5T187 [Target identity:22%; Query identity:100%]
SHC-transforming protein 1 {ECO:0000313|Ensembl:ENSP00000398864}
Q8NFT0 [Target identity:9%; Query identity:100%]
Src homology 2 domain-containing transforming protein 1 isoform p52 {ECO:0000313|EMBL:AAM61860.1}

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Predicted intracellular proteins
Mitochondrial proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0001525 [angiogenesis]
GO:0004713 [protein tyrosine kinase activity]
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006987 [activation of signaling protein activity involved in unfolded protein response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007265 [Ras protein signal transduction]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030168 [platelet activation]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040008 [regulation of growth]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045740 [positive regulation of DNA replication]
GO:0046875 [ephrin receptor binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0070435 [Shc-EGFR complex]

583

62.8

SHC1-002

ENSP00000401303
ENST00000448116

P29353
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P29353 [Direct mapping]
SHC-transforming protein 1
B4DL02 [Target identity:89%; Query identity:100%]
cDNA FLJ56101, highly similar to SHC-transforming protein 1 {ECO:0000313|EMBL:BAG59364.1}
Q8NFT1 [Target identity:28%; Query identity:100%]
Src homology 2 domain-containing transforming protein 1 isoform p66 {ECO:0000313|EMBL:AAM61859.1}
Q5T181 [Target identity:23%; Query identity:100%]
SHC-transforming protein 1 {ECO:0000313|Ensembl:ENSP00000396162}
Q5T187 [Target identity:22%; Query identity:100%]
SHC-transforming protein 1 {ECO:0000313|Ensembl:ENSP00000398864}
Q8NFT0 [Target identity:9%; Query identity:100%]
Src homology 2 domain-containing transforming protein 1 isoform p52 {ECO:0000313|EMBL:AAM61860.1}

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Predicted intracellular proteins
Mitochondrial proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0001525 [angiogenesis]
GO:0004713 [protein tyrosine kinase activity]
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006987 [activation of signaling protein activity involved in unfolded protein response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007265 [Ras protein signal transduction]
GO:0007507 [heart development]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0016337 [single organismal cell-cell adhesion]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030168 [platelet activation]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0031532 [actin cytoskeleton reorganization]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040008 [regulation of growth]
GO:0042127 [regulation of cell proliferation]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045740 [positive regulation of DNA replication]
GO:0046875 [ephrin receptor binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0070435 [Shc-EGFR complex]

584

62.9

SHC1-003

ENSP00000357434
ENST00000368449

X6R6D0
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X6R6D0 [Target identity:100%; Query identity:100%]
SHC-transforming protein 1 {ECO:0000313|Ensembl:ENSP00000357434}
Q5T187 [Target identity:36%; Query identity:100%]
SHC-transforming protein 1 {ECO:0000313|Ensembl:ENSP00000398864}

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Phobius predicted secreted proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001525 [angiogenesis]
GO:0005515 [protein binding]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035556 [intracellular signal transduction]

354

38.6

SHC1-004

ENSP00000404908
ENST00000414115

Q5T188
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Q5T188 [Target identity:100%; Query identity:100%]
SHC-transforming protein 1 {ECO:0000313|Ensembl:ENSP00000404908}

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SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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GO:0001525 [angiogenesis]
GO:0005515 [protein binding]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035556 [intracellular signal transduction]

200

21.5

SHC1-005

ENSP00000398864
ENST00000444179

Q5T187
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Q5T187 [Target identity:99%; Query identity:100%]
SHC-transforming protein 1 {ECO:0000313|Ensembl:ENSP00000398864}

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Phobius predicted secreted proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0005515 [protein binding]
GO:0035556 [intracellular signal transduction]

130

14.5

SHC1-006

ENSP00000357438
ENST00000368453

P29353
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P29353 [Direct mapping]
SHC-transforming protein 1
Q5T181 [Target identity:28%; Query identity:100%]
SHC-transforming protein 1 {ECO:0000313|Ensembl:ENSP00000396162}
Q5T187 [Target identity:27%; Query identity:100%]
SHC-transforming protein 1 {ECO:0000313|Ensembl:ENSP00000398864}
Q8NFT0 [Target identity:11%; Query identity:100%]
Src homology 2 domain-containing transforming protein 1 isoform p52 {ECO:0000313|EMBL:AAM61860.1}

Show » « Hide

Predicted intracellular proteins
Mitochondrial proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005068 [transmembrane receptor protein tyrosine kinase adaptor activity]
GO:0005154 [epidermal growth factor receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005159 [insulin-like growth factor receptor binding]
GO:0005168 [neurotrophin TRKA receptor binding]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006987 [activation of signaling protein activity involved in unfolded protein response]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007176 [regulation of epidermal growth factor-activated receptor activity]
GO:0007265 [Ras protein signal transduction]
GO:0007596 [blood coagulation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030168 [platelet activation]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0040008 [regulation of growth]
GO:0044267 [cellular protein metabolic process]
GO:0045087 [innate immune response]
GO:0045740 [positive regulation of DNA replication]
GO:0046875 [ephrin receptor binding]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0070435 [Shc-EGFR complex]

474

51.7

SHC1-007

ENSP00000357435
ENST00000368450

P29353
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P29353 [Direct mapping]
SHC-transforming protein 1
X6R6D0 [Target identity:74%; Query identity:100%]
SHC-transforming protein 1 {ECO:0000313|Ensembl:ENSP00000357434}
Q5T181 [Target identity:28%; Query identity:100%]
SHC-transforming protein 1 {ECO:0000313|Ensembl:ENSP00000396162}
Q5T187 [Target identity:27%; Query identity:100%]
SHC-transforming protein 1 {ECO:0000313|Ensembl:ENSP00000398864}
Q8NFT0 [Target identity:11%; Query identity:100%]
Src homology 2 domain-containing transforming protein 1 isoform p52 {ECO:0000313|EMBL:AAM61860.1}

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Predicted intracellular proteins
Mitochondrial proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

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473

51.6

SHC1-008

ENSP00000398441
ENST00000412170

Q5T182
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Q5T182 [Target identity:100%; Query identity:100%]
SHC-transforming protein 1 {ECO:0000313|Ensembl:ENSP00000398441}
Q5T181 [Target identity:68%; Query identity:100%]
SHC-transforming protein 1 {ECO:0000313|Ensembl:ENSP00000396162}
Q8NFT0 [Target identity:27%; Query identity:100%]
Src homology 2 domain-containing transforming protein 1 isoform p52 {ECO:0000313|EMBL:AAM61860.1}

Show » « Hide

Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0001525 [angiogenesis]
GO:0005515 [protein binding]
GO:0030971 [receptor tyrosine kinase binding]
GO:0035556 [intracellular signal transduction]

200

SHC1-009

ENSP00000396162
ENST00000366442

Q5T181
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Q5T181 [Target identity:100%; Query identity:100%]
SHC-transforming protein 1 {ECO:0000313|Ensembl:ENSP00000396162}
Q8NFT0 [Target identity:40%; Query identity:100%]
Src homology 2 domain-containing transforming protein 1 isoform p52 {ECO:0000313|EMBL:AAM61860.1}

Show » « Hide

Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

Show » « Hide

GO:0005515 [protein binding]
GO:0035556 [intracellular signal transduction]

137

14.8

SHC1-010

ENSP00000396333
ENST00000444664

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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)

297

32.5

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.