FDPS

GENE INFORMATION

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Gene name

FDPS

Synonyms

Description

Farnesyl diphosphate synthase (HGNC Symbol)

Entrez gene summary

This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]

Chromosome

1

Cytoband

q22

Chromosome location (bp)

155308748 - 155320666

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000160752 (version 78.38)

Entrez gene

2224

UniProt

P14324 (UniProt - Evidence at protein level)

neXtProt

NX_P14324

Antibodypedia

FDPS antibodies
 

PROTEIN VIEW

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FDPS-001
 
FDPS-002
 
FDPS-004
 
FDPS-007
 
FDPS-019
 
FDPS-020
 
FDPS-021
 
FDPS-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FDPS-001 ENSP00000349078
ENST00000356657
P14324
Show all »
Show » Show » 419 48.3 No 0
FDPS-002 ENSP00000357340
ENST00000368356
P14324
Show all »
Show » Show » 419 48.3 No 0
FDPS-004 ENSP00000479557
ENST00000491013
Show » Show » 274 31.8 No 0
FDPS-007 ENSP00000484099
ENST00000465559
Show » Show » 174 20 No 0
FDPS-019 ENSP00000478235
ENST00000612683
P14324
Show all »
Show » Show » 353 40.5 No 0
FDPS-020 ENSP00000480142
ENST00000467076
P14324
Show all »
Show » Show » 353 40.5 No 0
FDPS-021 ENSP00000391755
ENST00000447866
P14324
Show all »
Show » Show » 353 40.5 No 0
FDPS-201 ENSP00000483188
ENST00000611010
Show » Show » 248 28.6 No 0