DCD

GENE INFORMATION

? »

Gene name

DCD (HGNC Symbol)

Synonyms

AIDD, DCD-1, DSEP, HCAP, PIF

Description

Dermcidin (HGNC Symbol)

Entrez gene summary

This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

Chromosome

12

Cytoband

q13.2

Chromosome location (bp)

54644591 - 54648493

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000161634 (version 78.38)

Entrez gene

117159

UniProt

P81605 (UniProt - Evidence at protein level)

neXtProt

NX_P81605

Antibodypedia

DCD antibodies
 

PROTEIN VIEW

? »
 
 
 
DCD-001
 
DCD-003
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DCD-001 ENSP00000293371
ENST00000293371
P81605
Show all »
Show » Show » 110 11.3 Yes 0
DCD-003 ENSP00000406773
ENST00000456047
P81605
Show all »
Show » Show » 121 12.4 Yes 0