FUBP1

GENE INFORMATION

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Gene name

FUBP1 (HGNC Symbol)

Synonyms

FBP, FUBP

Description

Far upstream element (FUSE) binding protein 1 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Chromosome

1

Cytoband

p31.1

Chromosome location (bp)

77944055 - 77979110

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162613 (version 78.38)

Entrez gene

8880

UniProt

Q96AE4 (UniProt - Evidence at protein level)

neXtProt

NX_Q96AE4

Antibodypedia

FUBP1 antibodies
 

PROTEIN VIEW

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FUBP1-002
 
FUBP1-003
 
FUBP1-004
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

FUBP1-002 ENSP00000359804
ENST00000370768
Q96AE4
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Show » Show » 644 67.6 No 0
FUBP1-003 ENSP00000359803
ENST00000370767
E9PEB5
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Show » Show » 655 68.9 No 0
FUBP1-004 ENSP00000402630
ENST00000421641
C9JSZ1
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Show » Show » 232 24 No 0