ATF3 - Gene info - The Human Protein Atlas

Gene name

ATF3

Synonyms

Description

Activating transcription factor 3 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]

Chromosome

Cytoband

q32.3

Chromosome location (bp)

212565334 - 212620777

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000162772 (version 78.38)

Entrez gene

467

UniProt

P18847 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATF3-001

ENSP00000344352
ENST00000341491

P18847
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P18847 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-3
Q5VTZ4 [Target identity:96%; Query identity:100%]
Cyclic AMP-dependent transcription factor ATF-3 {ECO:0000313|Ensembl:ENSP00000355948}

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Predicted intracellular proteins
Transcription factors
Basic domains
Protein evidence (Kim et al 2014)

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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription]
GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006094 [gluconeogenesis]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006987 [activation of signaling protein activity involved in unfolded protein response]
GO:0008284 [positive regulation of cell proliferation]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0035914 [skeletal muscle cell differentiation]
GO:0042802 [identical protein binding]
GO:0043565 [sequence-specific DNA binding]
GO:0044267 [cellular protein metabolic process]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]

181

20.6

ATF3-002

ENSP00000355948
ENST00000366981

Q5VTZ4
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Q5VTZ4 [Target identity:100%; Query identity:100%]
Cyclic AMP-dependent transcription factor ATF-3 {ECO:0000313|Ensembl:ENSP00000355948}

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)

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GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]

175

ATF3-004

ENSP00000355950
ENST00000366983

P18847
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P18847 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-3
Q8NG55 [Target identity:14%; Query identity:100%]
ATF3deltaZip2 {ECO:0000313|EMBL:BAC05510.1}

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Predicted intracellular proteins
Transcription factors
Basic domains
Protein evidence (Kim et al 2014)

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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription]
GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0003714 [transcription corepressor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006987 [activation of signaling protein activity involved in unfolded protein response]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0042802 [identical protein binding]
GO:0043565 [sequence-specific DNA binding]
GO:0044267 [cellular protein metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]

135

15.2

ATF3-006

ENSP00000336908
ENST00000336937

P18847
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P18847 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-3
Q8NG55 [Target identity:17%; Query identity:100%]
ATF3deltaZip2 {ECO:0000313|EMBL:BAC05510.1}

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Predicted intracellular proteins
Transcription factors
Basic domains
Protein evidence (Kim et al 2014)

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106

12.3

ATF3-007

ENSP00000355952
ENST00000366985

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Predicted intracellular proteins
Protein evidence (Kim et al 2014)

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GO:0003677 [DNA binding]
GO:0003700 [sequence-specific DNA binding transcription factor activity]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]

153

17.6

ATF3-009

ENSP00000480606
ENST00000613104

P18847
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P18847 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-3

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Predicted intracellular proteins
Transcription factors
Basic domains
Protein evidence (Kim et al 2014)

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124

14.3

ATF3-201

ENSP00000355954
ENST00000366987

P18847
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Predicted intracellular proteins
Transcription factors
Basic domains
Protein evidence (Kim et al 2014)

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181

20.6

ATF3-202

ENSP00000483576
ENST00000613954

P18847
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P18847 [Direct mapping]
Cyclic AMP-dependent transcription factor ATF-3

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Predicted intracellular proteins
Transcription factors
Basic domains
Protein evidence (Kim et al 2014)

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124

14.3

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.